Background Sepsis, the dysregulated host response to infection, triggers abnormal pro-
coagulant and pro-inflammatory host responses. Limitations in early disease intervention …

Introduction Protein C, because of its central role in hemostasis, plays an integral role in the
host response to infection. Protein C depletion, resulting from increased consumption …

Introduction Serial alterations in protein C levels appear to correlate with disease severity in
patients with severe sepsis, and it may be possible to tailor severe sepsis therapy with the …

Introduction C-reactive protein (CRP) has been shown to be a valuable marker in the
diagnosis of infection and in monitoring its response to antibiotics. Our objective was to …

Abstract Introduction Drotrecogin alfa (activated; DrotAA) treatment, a 96-hour infusion,
reduces 28-day mortality in severe sepsis to approximately 25%. The question remains …

Introduction Community-acquired pneumonia (CAP) requiring intensive care unit (ICU)
admission remains a severe medical condition, presenting ICU mortality rates reaching …

Background This study investigated changes in plasma level of soluble endothelial protein
C receptor (sEPCR) in association with outcome in patients with septic shock. We explored …

Abstract Introduction PROWESS (Recombinant Human Activated Protein C Worldwide
Evaluation in Severe Sepsis) was a phase III, randomized, double blind, placebo controlled …

Introduction Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic
functions. In a previous review, we identified 3370 references reporting on 178 different …

Introduction Current criteria for early diagnosis of coagulopathy in sepsis are limited. We
postulated that coagulopathy is already complicated with sepsis in the initial phase, and …