HIV-specific T cells are necessary for control of HIV-1 replication but are largely insufficient
for viral clearance. This is due in part to these cells' recognition of immunodominant but …

Activation, infection, and eventual depletion of human immunodeficiency virus (HIV)-specific
cluster of differentiation 4 (CD4) T cells are the crucial pathogenetic events in acquired …

Despite the ability of antiretroviral therapy to minimize human immunodeficiency virus type 1
(HIV-1) replication and increase the duration and quality of patients' lives, the health …

There is a desperate need for effective therapies to fight chronic viral infections. The immune
response is normally fastidious at controlling the majority of viral infections and a therapeutic …

ABSTRACT AIDS virus infections are rarely controlled by cell-mediated immunity, in part due
to viral immune evasion and immunodeficiency resulting from CD4+ T-cell infection. One …

The HIV-specific cytotoxic T lymphocyte (CTL) response is a critical component in controlling
viral replication in vivo, but ultimately fails in its ability to eradicate the virus. Our intent in …

Antiretroviral therapy (ART) is unable to eradicate human immunodeficiency virus type 1
(HIV-1) infection. Therefore, there is an urgent need to develop novel therapies for this …

Engineered T cells hold great promise to become part of an effective HIV cure strategy, but it
is currently unclear how best to redirect T cells to target HIV. To gain insight, we generated …

HIV-infected individuals successfully controlling viral replication via antiretroviral therapy
often have a compromised HIV-specific T-cell immune response due to the lack of CD4 T …

Although anti-retroviral therapy (ART) is successful in suppressing HIV-1 replication, HIV
latently infected reservoirs are not eliminated, representing a major hurdle in efforts to …