Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity

M Pigeyre, FT Yazdi, Y Kaur, D Meyre - Clinical science, 2016 - portlandpress.com
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Beyond the fourth wave of genome-wide obesity association studies

CH Sandholt, T Hansen, O Pedersen - Nutrition & diabetes, 2012 - nature.com
Obesity and related complications are major health burdens. Almost 700 million adults are
currently obese globally and the prevalence is predicted to rise towards 2030. The sudden …

Genetics and epigenetics in the obesity phenotyping scenario

K Trang, SFA Grant - Reviews in endocrine and metabolic disorders, 2023 - Springer
Obesity is a common complex trait that elevates the risk for various diseases, including type
2 diabetes and cardiovascular disease. A combination of environmental and genetic factors …

Role of gut microbiota in the aetiology of obesity: proposed mechanisms and review of the literature

MJ Khan, K Gerasimidis, CA Edwards… - Journal of …, 2016 - Wiley Online Library
The aetiology of obesity has been attributed to several factors (environmental, dietary,
lifestyle, host, and genetic factors); however none of these fully explain the increase in the …

Insights into the multifactorial causation of obesity by integrated genetic and epigenetic analysis

S Diels, W Vanden Berghe, W Van Hul - Obesity Reviews, 2020 - Wiley Online Library
Obesity is a highly heritable multifactorial disease that places an enormous burden on
human health. Its increasing prevalence and the concomitant‐reduced life expectancy has …

The contribution of genetics and environment to obesity

D Albuquerque, C Nóbrega, L Manco… - British medical …, 2017 - academic.oup.com
Background Obesity is a global health problem mainly attributed to lifestyle changes such as
diet, low physical activity or socioeconomics factors. However, several evidences …

Gene-diet interaction and precision nutrition in obesity

Y Heianza, L Qi - International journal of molecular sciences, 2017 - mdpi.com
The rapid rise of obesity during the past decades has coincided with a profound shift of our
living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical …

The epigenetic connection between the gut microbiome in obesity and diabetes

M Sharma, Y Li, ML Stoll, TO Tollefsbol - Frontiers in genetics, 2020 - frontiersin.org
Metabolic diseases are becoming an alarming health issue due to elevated incidences of
these diseases over the past few decades. Various environmental factors are associated …

Fat: an evolving issue

JR Speakman, S O'Rahilly - Disease models & mechanisms, 2012 - journals.biologists.com
Work on obesity is evolving, and obesity is a consequence of our evolutionary history. In the
space of 50 years, we have become an obese species. The reasons why can be addressed …

Epigenetics of obesity

A Lopomo, E Burgio, L Migliore - Progress in molecular biology and …, 2016 - Elsevier
Obesity is a metabolic disease, which is becoming an epidemic health problem: it has been
recently defined in terms of Global Pandemic. Over the years, the approaches through …