Diffusion tensor imaging (DTI) allows the in vivo imaging of pathological white matter
alterations, either with unbiased voxel-wise or hypothesis-guided tract-based analysis …

Previous diffusion tensor imaging (DTI) studies have shown white matter pathology in
amyotrophic lateral sclerosis (ALS), predominantly in the motor pathways. Further these …

Objective: The potential of magnetic resonance imaging (MRI) as a technical biomarker for
cerebral microstructural alterations in neurodegenerative diseases is under investigation. In …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. However, no reliable
biomarkers have been identified to represent the clinical status. This study aimed to …

Diffusion tensor imaging (DTI) for assessing ALS-associated white matter alterations has still
not reached the level of a neuroimaging biomarker. Since large-scale multicentre DTI …

Objective Damage to the cerebral tissue structural connectivity associated with amyotrophic
lateral sclerosis (ALS), which extends beyond the motor pathways, can be visualised by …

Objective To assess the relationship between clinically assessed Upper Motor Neuron
(UMN) disease in Amyotrophic Lateral Sclerosis (ALS) and local diffusion alterations …

Background The results of recent diffusion tensor imaging (DTI) studies on amyotrophic
lateral sclerosis (ALS) are inconclusive and controversial. We performed a voxel-based …

The potential of multiparametric quantitative neuroimaging has been extensively discussed
as a diagnostic tool in amyotrophic lateral sclerosis (ALS). In the past, the integration of …

Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder,
caused by progressive loss of motor neurons. Changes are widespread in the subcortical …