Targeting CXCL12/CXCR4 axis in tumor immunotherapy
Chemokines, which have chemotactic abilities, are comprised of a family of small cytokines
with 8-10 kilodaltons. Chemokines work in immune cells by trafficking and regulating cell …
with 8-10 kilodaltons. Chemokines work in immune cells by trafficking and regulating cell …
The CXCL12 (SDF-1)/CXCR4 chemokine axis: Oncogenic properties, molecular targeting, and synthetic and natural product CXCR4 inhibitors for cancer therapy
Z Yu, CAO Han-Bo, LI Wen-Jun, Z Li - Chinese journal of natural medicines, 2018 - Elsevier
Abstract Chemokine 12 (CXCL12), also known as stromal cell derived factor-1 (SDF-1) and
a member of the CXC chemokine subfamily, is ubiquitously expressed in many tissues and …
a member of the CXC chemokine subfamily, is ubiquitously expressed in many tissues and …
CXCL12 (SDF-1)/CXCR4 pathway in cancer
BA Teicher, SP Fricker - Clinical cancer research, 2010 - AACR
Chemokines, small proinflammatory chemoattractant cytokines that bind to specific G-protein-
coupled seven-span transmembrane receptors, are major regulators of cell trafficking and …
coupled seven-span transmembrane receptors, are major regulators of cell trafficking and …
CXCL5: A coachman to drive cancer progression
J Deng, R Jiang, E Meng, H Wu - Frontiers in Oncology, 2022 - frontiersin.org
Chemokines are a class of pro-inflammatory cytokines that can recruit and activate
chemotactic cells. C‐X‐C motif chemokine ligand 5 (CXCL5) is a member of the chemokine …
chemotactic cells. C‐X‐C motif chemokine ligand 5 (CXCL5) is a member of the chemokine …
The role of the CXCL12/CXCR4/CXCR7 chemokine axis in cancer
Chemokines are a family of small, secreted cytokines which regulate a variety of cell
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …
The role of CXCL12 in tumor microenvironment
W Meng, S Xue, Y Chen - Gene, 2018 - Elsevier
The chemokine ligand CXC motif chemokine ligand 12 (CXCL12) is a kind of small
molecules of cytokines that widely expressed in diversified tissues. Recent evidence …
molecules of cytokines that widely expressed in diversified tissues. Recent evidence …
CXCL13/CXCR5 signaling axis in cancer
The tumor microenvironment comprises stromal and tumor cells which interact with each
other through complex cross-talks that are mediated by a variety of growth factors, cytokines …
other through complex cross-talks that are mediated by a variety of growth factors, cytokines …
Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12
Although chemokines are well established to function in immunity and endothelial cell
activation and proliferation, a rapidly growing literature suggests that CXC Chemokine …
activation and proliferation, a rapidly growing literature suggests that CXC Chemokine …
Translating an antagonist of chemokine receptor CXCR4: from bench to bedside
D Wong, W Korz - Clinical Cancer Research, 2008 - AACR
The majority of current cancer therapies focus on a primary tumor approach. However, it is
metastases that cause the majority of cancer deaths. The metastatic process has been …
metastases that cause the majority of cancer deaths. The metastatic process has been …
The intricate role of CXCR4 in cancer
S Chatterjee, BB Azad, S Nimmagadda - Advances in cancer research, 2014 - Elsevier
Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …