Eukaryotic pathogens typically follow a complex life cycle, including host switch and
morphologically distinct forms. Parasite stage conversion offers exceptional opportunities for …

Despite nearly 100 years of research and control efforts, malaria remains one of the most
important infectious diseases. An efficient vaccine would be a powerful to tool to reduce …

A highly efficacious malaria vaccine that prevents disease and breaks the cycle of infection
remains an aspirational goal of medicine. Whole parasite vaccines based on the sporozoite …

Recently it has been shown in rodent malaria models that immunisation with genetically
attenuated Plasmodium parasites can confer sterile protection against challenge with …

Plasmodium undergoes an obligate liver phase before the onset of malaria, which is caused
exclusively by cyclic propagation of the parasite inside erythrocytes. The diagnostically …

Now, 27 years following the cloning of malaria antigens with the promise of the rapid
development of a malaria vaccine, we face significant obstacles that are belatedly being …

Malaria, caused by Plasmodium parasite infection, continues to be one of the leading
causes of worldwide morbidity and mortality. Development of an effective vaccine has been …

Liver-stage development of Plasmodium parasites represents a dramatic expansion phase
for the malarial parasite between vector transmission and onset of the pathogenic blood …

The worldwide burden of malaria can be substantially reduced using existing public health
interventions. However, elimination of Plasmodium will require fundamentally different …

Despite the significant gains made with control efforts, malaria continues to be a dominant
infectious disease threat in many parts of the world [1]. Malaria in humans is caused by …