Arrested Plasmodium liver stages as experimental anti-malaria vaccines
K Matuschewski, JC Hafalla, S Borrmann… - Human …, 2011 - Taylor & Francis
Eukaryotic pathogens typically follow a complex life cycle, including host switch and
morphologically distinct forms. Parasite stage conversion offers exceptional opportunities for …
morphologically distinct forms. Parasite stage conversion offers exceptional opportunities for …
Protective immunity against malaria liver stage after vaccination with live parasites
L Renia - Parasite, 2008 - parasite-journal.org
Despite nearly 100 years of research and control efforts, malaria remains one of the most
important infectious diseases. An efficient vaccine would be a powerful to tool to reduce …
important infectious diseases. An efficient vaccine would be a powerful to tool to reduce …
Designer parasites: genetically engineered Plasmodium as vaccines to prevent malaria infection
A highly efficacious malaria vaccine that prevents disease and breaks the cycle of infection
remains an aspirational goal of medicine. Whole parasite vaccines based on the sporozoite …
remains an aspirational goal of medicine. Whole parasite vaccines based on the sporozoite …
A new approach to generate a safe double-attenuated Plasmodium liver stage vaccine
A Nagel, M Prado, A Heitmann, S Tartz… - International journal for …, 2013 - Elsevier
Recently it has been shown in rodent malaria models that immunisation with genetically
attenuated Plasmodium parasites can confer sterile protection against challenge with …
attenuated Plasmodium parasites can confer sterile protection against challenge with …
Protective immunity against malaria by 'natural immunization': a question of dose, parasite diversity, or both?
S Borrmann, K Matuschewski - Current Opinion in Immunology, 2011 - Elsevier
Plasmodium undergoes an obligate liver phase before the onset of malaria, which is caused
exclusively by cyclic propagation of the parasite inside erythrocytes. The diagnostically …
exclusively by cyclic propagation of the parasite inside erythrocytes. The diagnostically …
A whole parasite vaccine to control the blood stages of Plasmodium–the case for lateral thinking
MF Good - Trends in parasitology, 2011 - cell.com
Now, 27 years following the cloning of malaria antigens with the promise of the rapid
development of a malaria vaccine, we face significant obstacles that are belatedly being …
development of a malaria vaccine, we face significant obstacles that are belatedly being …
Mechanisms of stage-transcending protection following immunization of mice with late liver stage-arresting genetically attenuated malaria parasites
BK Sack, GJ Keitany, AM Vaughan, JL Miller… - PLoS …, 2015 - journals.plos.org
Malaria, caused by Plasmodium parasite infection, continues to be one of the leading
causes of worldwide morbidity and mortality. Development of an effective vaccine has been …
causes of worldwide morbidity and mortality. Development of an effective vaccine has been …
Vaccine-Like Immunity against Malaria by Repeated Causal-Prophylactic Treatment of Liver-Stage Plasmodium Parasites
ED Putrianti, O Silvie, M Kordes… - The Journal of …, 2009 - academic.oup.com
Liver-stage development of Plasmodium parasites represents a dramatic expansion phase
for the malarial parasite between vector transmission and onset of the pathogenic blood …
for the malarial parasite between vector transmission and onset of the pathogenic blood …
Targeting Plasmodium liver stages: better late than never
S Borrmann, K Matuschewski - Trends in molecular medicine, 2011 - cell.com
The worldwide burden of malaria can be substantially reduced using existing public health
interventions. However, elimination of Plasmodium will require fundamentally different …
interventions. However, elimination of Plasmodium will require fundamentally different …
Genetically attenuated malaria parasites as vaccines
AM Vaughan, SHI Kappe - Expert review of vaccines, 2017 - Taylor & Francis
Despite the significant gains made with control efforts, malaria continues to be a dominant
infectious disease threat in many parts of the world [1]. Malaria in humans is caused by …
infectious disease threat in many parts of the world [1]. Malaria in humans is caused by …