Nucleic acid–based assemblies that interact with each other and further communicate with
the cellular machinery in a controlled manner represent a new class of reconfigurable …

DNA and RNA of both natural and synthetic origin can elicit strong immune responses in
higher organisms. Computer-aided design in conjunction with high-throughput sequencing …

944RNA is a versatile biomaterial that can be used to engineer nanoassemblies for
personalized treatment of various diseases. Despite promising advancements, the design of …

The precise regulation of interactions of specific immunological components is crucial for
controllable immunomodulation, yet it remains a great challenge. With the assistance of …

Since the discovery of the double-helix structure in 1953, nucleic acids have been
developed from natural genetic codes into functional building blocks in a wide range of …

Gene therapeutics including siRNAs, anti‐sense oligos, messenger RNAs, and CRISPR
ribonucleoprotein complexes offer unmet potential to treat over 7,000 known genetic …

Nucleic acids are programmable and biocompatible polymers that have beneficial uses in
nanotechnology with broad applications in biosensing and therapeutics. In some cases …

Although RNA and DNA are best known for their capacity to encode biological information, it
has become increasingly clear over the past few decades that these biomolecules are also …

Structural DNA nanotechnology seeks to create architectures of highly precise dimensions
using the physical property that short lengths of DNA behave as rigid rods and the chemical …

Immune cells sense, communicate, and logically integrate a multitude of environmental
signals to make important cell‐fate decisions and fulfill their effector functions. These …