Neurotoxicity studies aim at understanding the toxic effects and mechanisms of toxicants to
human central nervous systems (CNS). However, human brains are the most complex …

Human brain is undoubtedly the most complex organ in the body. Thus, it is difficult to
develop adequate and at the same time human relevant test systems and models to cover …

The prevalence of environmental problems and the increasing risk of human exposure to
environmental pollutants have become a global concern. The increasing environmental …

The currently accepted methods for neurotoxicity (NT) testing rely on animal studies.
However, high costs and low testing throughput hinder their application for large numbers of …

Highlights•3D CNS organoids share architecture and functions resembling the human
brain.•Recapitulating key features of the early-stage brain under a controlled …

The human brain is a complicated and precisely organized organ. Exogenous chemicals,
such as pollutants, drugs, and industrial chemicals, may affect the biological processes of …

We present a hiPSC-based 3D in vitro system suitable to test neurotoxicity (NT). Human
iPSCs-derived 3D neurospheres grown in 96-well plate format were characterized timewise …

Toxicity testing is a crucial step in the development and approval of chemical compounds for
human contact and consumption. However, existing model systems often fall short in their …

Understanding the complexities of the human brain and its associated disorders poses a
significant challenge in neuroscience. Traditional research methods have limitations in …

Neurological disorders affect millions of people worldwide and appear to be on the rise.
Whereas the reason for this increase remains unknown, environmental factors are a …