Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction

MV Murlykina, OV Kolomiets… - Beilstein Journal of …, 2019 - beilstein-journals.org
Abstract Substituted 1H-pyrazolo [3, 4-b] pyridine-4-and 1H-pyrazolo [3, 4-b] pyridine-6-
carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction …

Synthesis of imidazo [1, 2-a] pyridine-containing peptidomimetics by tandem of Groebke–Blackburn–Bienaymé and Ugi reactions

OV Kolomiiets, AV Tsygankov… - Beilstein Journal of …, 2023 - beilstein-journals.org
Peptidomimetics with a substituted imidazo [1, 2-a] pyridine fragment were synthesized by a
tandem of Groebke–Blackburn–Bienaymé and Ugi reactions. The target products contain …

New four-component Ugi-type reaction. Synthesis of 3-methyl-1-oxo-1, 3, 4, 6, 11, 11a-hexahydro-2H-pyrazino [1, 2-b] isoquinoline-3-carboxamides

AP Ilyn, AS Trifilenkov, DI Kovrigin… - Heterocyclic …, 2006 - degruyter.com
A small-sized library of novel 3, 4, 11, 1 la-tetrahydro-2#-pyrazino [l, 2-0] isoquinolin-l (6//)-
ones is synthesized. Key synthetic step is based on a new variant of Ugi four component …

8, 9, 10, 10a-tetrahydro-6H-tetrazolo [1, 5-a] pyrrolo [2, 1-c] pyrazines: New heterocyclic frameworks generated by an Ugi-type multicomponent reaction

V Franckevičius, DA Longbottom, RM Turner… - Synthesis, 2006 - thieme-connect.com
Thieme E-Journals - Synthesis / Full Text DE EN Home Products Journals Books Book Series
Service Library Service Help Contact Portal SYNTHESIS Full-text search Full-text search Author …

Tandem multicomponent reactions toward the design and synthesis of novel antibacterial and cytotoxic motifs

MH Semreen, R El-Awady, R Abu-Odeh… - Current medicinal …, 2013 - ingentaconnect.com
The synthesis of polysubstituted imidazopyridines and imidazopyrazines through the
orthogonal union of Groebke-Blackburn and Ugi reactions is described. These motifs were …

Tunable regioselective synthesis of pyrazolo [3, 4-d] pyrimidine derivatives via aza-Wittig cyclization and dimroth-type rearrangement

T Wang, J Xiong, W Wang, R Li, X Tang, F Xiong - RSC Advances, 2015 - pubs.rsc.org
A novel tunable regioselective synthesis of pyrazolo [3, 4-d] pyrimidine derivatives via aza-
Wittig/Ag (I) or base-promoted tandem reaction has been developed. This approach …

Efficient one-pot synthesis of amino-benzotriazolodiazocinone scaffolds via catalyst-free tandem Ugi–Huisgen reactions

TMA Barlow, M Jida, K Guillemyn, D Tourwe… - Organic & …, 2016 - pubs.rsc.org
Herein we describe a catalyst-free, one-pot procedure employing an Ugi-4CR between
propargyl glycine, functionalised 2-azidoanilines, different isocyanides and aldehydes …

Ugi 5-center-4-component reaction of α-amino aldehydes and its application in synthesis of 2-oxopiperazines

M Splandesci, MZ Wróbel, ID Madura, M Dawidowski - Molecular Diversity, 2024 - Springer
A synthetic route leading to densely functionalized 2-oxopiperazines is presented. The
strategy employs a 5-center-4-component variant of Ugi multicomponent reaction followed …

Three-component regioselective synthesis and antibacterial evaluation of new arene-linked bis(pyrazolo[1,5-a]pyrimidine) hybrids

SMH Sanad, AEM Mekky - Synthetic Communications, 2023 - Taylor & Francis
In the current study, a three-component protocol was adopted to efficiently synthesize
butane-linked bis (pyrazolo [1, 5-a] pyrimidines) 1 attached to arene units in 74–81% yields …

5-Nitrofuran-Tagged Oxazolyl Pyrazolopiperidines: Synthesis and Activity against ESKAPE Pathogens

E Rogacheva, L Kraeva, A Lukin, L Vinogradova… - Molecules, 2023 - mdpi.com
A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has
been prepared in six stages with excellent regioselectivity. The testing of these compounds …