Brain glutathione levels–a novel biomarker for mild cognitive impairment and Alzheimer's disease
PK Mandal, S Saharan, M Tripathi, G Murari - Biological psychiatry, 2015 - Elsevier
Background Extant data from in vivo animal models and postmortem studies indicate that
Alzheimer's disease (AD) pathology is associated with reduction of the brain antioxidant …
Alzheimer's disease (AD) pathology is associated with reduction of the brain antioxidant …
[HTML][HTML] Altered central and blood glutathione in Alzheimer's disease and mild cognitive impairment: A meta-analysis
JJ Chen, M Thiyagarajah, J Song, C Chen… - Alzheimer's Research & …, 2022 - Springer
Background Increasing evidence implicates oxidative stress (OS) in Alzheimer disease (AD)
and mild cognitive impairment (MCI). Depletion of the brain antioxidant glutathione (GSH) …
and mild cognitive impairment (MCI). Depletion of the brain antioxidant glutathione (GSH) …
The emerging role of glutathione in Alzheimer's disease
S Saharan, PK Mandal - Journal of Alzheimer's Disease, 2014 - content.iospress.com
With millions of older individuals presently suffering from Alzheimer's disease (AD)
worldwide, AD is an unduly common form of dementia that exacts a heavy toll on affected …
worldwide, AD is an unduly common form of dementia that exacts a heavy toll on affected …
[HTML][HTML] In vivo brain GSH: MRS methods and clinical applications
F Bottino, M Lucignani, A Napolitano, F Dellepiane… - Antioxidants, 2021 - mdpi.com
Glutathione (GSH) is an important antioxidant implicated in several physiological functions,
including the oxidation− reduction reaction balance and brain antioxidant defense against …
including the oxidation− reduction reaction balance and brain antioxidant defense against …
Quantitation of in vivo brain glutathione conformers in cingulate cortex among age‐matched control, MCI, and AD patients using MEGA‐PRESS
D Shukla, PK Mandal, M Tripathi… - Human brain …, 2020 - Wiley Online Library
Oxidative stress (OS) plays an important role in Alzheimer's disease (AD) and glutathione
(GSH) mitigates this effect by maintaining redox‐imbalance and free‐radical neutralization …
(GSH) mitigates this effect by maintaining redox‐imbalance and free‐radical neutralization …
Glutathione relates to neuropsychological functioning in mild cognitive impairment
Background Mild cognitive impairment (MCI) represents an at-risk state for Alzheimer's
disease in which underlying pathophysiological mechanisms could be delineated. Oxidative …
disease in which underlying pathophysiological mechanisms could be delineated. Oxidative …
Brain oxidative stress: detection and mapping of anti-oxidant marker 'Glutathione'in different brain regions of healthy male/female, MCI and Alzheimer patients using …
PK Mandal, M Tripathi, S Sugunan - Biochemical and biophysical research …, 2012 - Elsevier
Glutathione (GSH) serves as an important anti-oxidant in the brain by scavenging harmful
reactive oxygen species that are generated during different molecular processes. The GSH …
reactive oxygen species that are generated during different molecular processes. The GSH …
Plasma GSH levels and Alzheimer's disease. A prospective approach.: Results from the HELIAD study
S Charisis, E Ntanasi, M Yannakoulia… - Free Radical Biology …, 2021 - Elsevier
Background Potential links between oxidative stress and the pathophysiology of Alzheimer's
disease (AD) have been reported in the existing literature. Biological markers of oxidative …
disease (AD) have been reported in the existing literature. Biological markers of oxidative …
Age-dependent and tissue-related glutathione redox status in a mouse model of Alzheimer's disease
C Zhang, C Rodriguez, J Spaulding… - Journal of …, 2012 - content.iospress.com
Glutathione plays an essential role in the intracellular antioxidant defense against oxidant
radicals, especially the• OH radical. To understand the early and progressive cellular …
radicals, especially the• OH radical. To understand the early and progressive cellular …
Hippocampal glutathione depletion with enhanced iron level in patients with mild cognitive impairment and Alzheimer's disease compared with healthy elderly …
Oxidative stress has been implicated in Alzheimer's disease, and it is potentially driven by
the depletion of primary antioxidant, glutathione, as well as elevation of the pro-oxidant, iron …
the depletion of primary antioxidant, glutathione, as well as elevation of the pro-oxidant, iron …