[HTML][HTML] Dual-modality optical diagnosis for precise in vivo identification of tumors in neurosurgery

M Zhu, W Chang, L Jing, Y Fan, P Liang, X Zhang… - Theranostics, 2019 - ncbi.nlm.nih.gov
In neurosurgery, the precise diagnosis and treatment of tumor diseases are challenging to
realize. Current clinical diagnoses lack fast and accurate intraoperative information …

[HTML][HTML] Quantitative Endogenous Fluorescence Analysis Discriminates Glioblastoma Tumor through Visible and NIR Excitation

H Mehidine, E Kaadou Mouawad, P Varlet, B Devaux… - Photonics, 2023 - mdpi.com
Nowadays, the ability to diagnose brain tumors intraoperatively and delineate their margins,
as accurately as possible, is of primordial importance during surgery. However, the exact …

In vivo real-time discrimination among glioma, infiltration zone, and normal brain tissue via autofluorescence technology

KT Chang, YY Lin, YY Lin, YL Lin, H Cheng, Y Chang… - World Neurosurgery, 2019 - Elsevier
Background Surgery is the first-line therapy for glioblastoma. There is evidence that extent of
resection is significantly associated with patient survival. Unfortunately, optimal surgical …

[HTML][HTML] Optical signatures derived from deep UV to NIR excitation discriminates healthy samples from low and high grades glioma

H Mehidine, A Chalumeau, F Poulon, F Jamme… - Scientific Reports, 2019 - nature.com
Among all the tumors of the central nervous system (CNS), glioma are the most deadly and
the most malignant. Surgical resection is the standard therapeutic method to treat this type of …

A novel integration of spectral-domain optical-coherence-tomography and laser-ablation system for precision treatment

Y Fan, B Zhang, W Chang, X Zhang, H Liao - International journal of …, 2018 - Springer
Purpose Complete resection of diseased lesions reduces the recurrence of cancer, making it
critical for surgical treatment. However, precisely resecting residual tumors is a challenge …

[HTML][HTML] Multimodal analysis of central nervous system tumor tissue endogenous fluorescence with multiscale excitation

F Poulon, A Chalumeau, F Jamme, J Pallud… - Frontiers in …, 2018 - frontiersin.org
The primary therapeutic approach for high-grade brain tumor is surgical resection. However,
identifying tumor margins in vivo remains a major challenge. Biopsy analysis remains the …

[HTML][HTML] Advances in optical molecular imaging for neural visualization

J Wei, C Liu, W Liang, X Yang, S Han - Frontiers in Bioengineering …, 2023 - frontiersin.org
Iatrogenic nerve injury is a significant complication in surgery, which can negatively impact
patients' quality of life. Currently, the main clinical neuroimaging methods, such as computed …

[HTML][HTML] The neurosurgical benefit of contactless in vivo optical coherence tomography regarding residual tumor detection: A clinical study

P Kuppler, P Strenge, B Lange, S Spahr-Hess… - Frontiers in …, 2023 - frontiersin.org
Purpose In brain tumor surgery, it is crucial to achieve complete tumor resection while
conserving adjacent noncancerous brain tissue. Several groups have demonstrated that …

[HTML][HTML] Real-time Brain Tumor imaging with endogenous fluorophores: a diagnosis proof-of-concept study on fresh human samples

F Poulon, J Pallud, P Varlet, M Zanello, F Chretien… - Scientific reports, 2018 - nature.com
The primary line of therapy for high-grade brain tumor is surgical resection, however,
identifying tumor margins in vivo remains a major challenge. Despite the progress in …

Multimodal imaging to explore endogenous fluorescence of fresh and fixed human healthy and tumor brain tissues

H Mehidine, M Sibai, F Poulon, J Pallud… - Journal of …, 2019 - Wiley Online Library
To complement a project toward label‐free optical biopsy and enhanced resection which the
overall goal is to develop a multimodal nonlinear endomicroscope, this multimodal …