The interaction between tumor cells and other cells in the tumor microenvironment (TME)
dramatically affects the behavior and progression of the disease. Fibroblasts, as a major …

Recapitulating the tumor microenvironment is a major challenge in the development of in
vitro tumor model for the study of cancer biology and therapeutic treatments. 3D multicellular …

Breast cancer (BC) is a leading cause of cancer death among women worldwide. To better
understand and predict therapeutic response in BC patient developing a fast, low-cost, and …

Modeling an accurate depiction of the tumor microenvironment,(TME), is essential to
observe the effect external factors might have on the tumor in vivo. In cancer therapy …

Tumor microenvironment plays a vital role in tumor progression, metastasis and
aggressiveness. The interaction between tumor and surrounding stromal cells, especially …

Currently, there has been a growing need for developing in vitro models to better reflect
organism response to chemotherapy at tissue level. For this reason, a microfluidic platform …

Three-dimensional (3D) tumor spheroids offer unprecedented capability for drug screening
because of their unique features such as spatial 3D structure, relevant physiological …

Multicellular 3D culture and interaction with stromal components are considered essential
elements in establishing a 'more clinically relevant'tumor model. Matrix-embedded 3D …

Abstract Engineered three-dimensional (3D) tissue culture platforms are useful for
reproducing and elucidating complex in vivo biological phenomena. Spheroids, 3D …

The interaction of cancer cells with the stromal cells and matrix in the tumor
microenvironment plays a key role in progression to metastasis. A better understanding of …