Antimicrobial resistance (AMR) has become a major problem in public health leading to an
estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and …

The world of antibiotic drug discovery and development is driven by the necessity to
overcome antibiotic resistance in common Gram-positive and Gram-negative pathogens …

With the advent of antibiotics, bacterial infections were supposed to be a thing of past.
However, this instead led to the selection and evolution of bacteria with mechanisms to …

Bacterial infections are an increasingly serious issue worldwide. The inability of existing
therapies to treat multidrug‐resistant pathogens has been recognized as an important …

The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …

Resistance of bacteria to many classes of antibiotics is an increasing problem worldwide.
Multidrug resistance efflux pumps are recognized as an important component of resistance …

Introduction: One of the possibilities for reducing the emergence and spread of antibiotic
resistance is the use of anti-resistance compounds capable of resensitizing resistant …

Traditional antimicrobials are increasingly suffering from the emergence of multidrug
resistance among pathogenic microorganisms. To overcome these deficiencies, a range of …

The increasing multi-drug resistance has become a major threat to the public health.
Overexpression of multidrug efflux pumps is one of the major mechanisms of drug resistance …

Antimicrobial resistance represents a significant challenge to future healthcare provision. An
acronym ESKAPEE has been derived from the names of the organisms recognised as the …