SpatialScope: A unified approach for integrating spatial and single-cell transcriptomics data using deep generative models

X Wan, J Xiao, SST Tam, M Cai, R Sugimura, Y Wang… - bioRxiv, 2023 - biorxiv.org
The rapid emergence of spatial transcriptomics (ST) technologies are revolutionizing our
under-standing of tissue spatial architecture and their biology. Current ST technologies …

Integrating spatial and single-cell transcriptomics data using deep generative models with SpatialScope

X Wan, J Xiao, SST Tam, M Cai, R Sugimura… - Nature …, 2023 - nature.com
The rapid emergence of spatial transcriptomics (ST) technologies is revolutionizing our
understanding of tissue spatial architecture and biology. Although current ST methods …

Deep learning in spatial transcriptomics: Learning from the next next-generation sequencing

AA Heydari, SS Sindi - BioRxiv, 2022 - biorxiv.org
Spatial transcriptomics (ST) technologies are rapidly becoming the extension of single-cell
RNA sequencing (scRNAseq), holding the potential of profiling gene expression at a single …

Tissue module discovery in single-cell-resolution spatial transcriptomics data via cell-cell interaction-aware cell embedding

Y Li, J Zhang, X Gao, QC Zhang - Cell Systems, 2024 - cell.com
Computational methods are desired for single-cell-resolution spatial transcriptomics (ST)
data analysis to uncover spatial organization principles for how individual cells exert tissue …

SC2Spa: a deep learning based approach to map transcriptome to spatial origins at cellular resolution

L Liao, E Madan, AM Palma, H Kim, A Kumar… - bioRxiv, 2023 - biorxiv.org
Integrating single cell RNAseq (scRNAseq) and spatial transcriptomics (ST) data is still
challenging especially when the spatial resolution is poor. For cellular resolution spatial …

[HTML][HTML] Deep learning in spatial transcriptomics: Learning from the next next-generation sequencing

AA Heydari, SS Sindi - Biophysics Reviews, 2023 - pubs.aip.org
Spatial transcriptomics (ST) technologies are rapidly becoming the extension of single-cell
RNA sequencing (scRNAseq), holding the potential of profiling gene expression at a single …

iSORT: An Integrative Method for Reconstructing Spatial Organization of Cells using Transfer Learning

Y Tan, A Wang, W Lin, Y Yan, J Shi - bioRxiv, 2024 - biorxiv.org
Understanding the cellular spatial organization is a paramountly important direction of
exploring the intricate functionalities of tissues and organs. However, conventional single …

STEM: A method for mapping single-cell and spatial transcriptomics data with transfer learning

M Hao, E Luo, Y Chen, Y Wu, C Li, S Chen, H Gao… - bioRxiv, 2022 - biorxiv.org
Profiling spatial variations of cellular composition and transcriptomic characteristics is
important for understanding the physiology and pathology of tissues in health or diseases …

STellaris: a web server for accurate spatial mapping of single cells based on spatial transcriptomics data

X Li, C Xiao, J Qi, W Xue, X Xu, Z Mu… - Nucleic acids …, 2023 - academic.oup.com
Single-cell RNA sequencing (scRNA-seq) provides insights into gene expression
heterogeneities in diverse cell types underlying homeostasis, development and pathological …

stPlus: a reference-based method for the accurate enhancement of spatial transcriptomics

C Shengquan, Z Boheng, C Xiaoyang… - …, 2021 - academic.oup.com
Motivation Single-cell RNA sequencing (scRNA-seq) techniques have revolutionized the
investigation of transcriptomic landscape in individual cells. Recent advancements in spatial …