Microbial natural product discovery programs face two main challenges today: rapidly
prioritizing strains for discovering new molecules and avoiding the rediscovery of already …

Rediscovery of known natural products hinders the discovery of new, unique scaffolds.
Efforts have mostly focused on streamlining the determination of what compounds are …

Microbial specialized metabolites are an important source of and inspiration for many
pharmaceuticals, biotechnological products and play key roles in ecological processes …

Secondary metabolites can be viewed as a chemical language, facilitating communication
between microorganisms. From an ecological point of view, this metabolite exchange is in …

Natural products profoundly impact many research areas, including medicine, organic
chemistry, and cell biology. However, discovery of new natural products suffers from a lack …

Introduction Natural products from culture collections have enormous impact in advancing
discovery programs for metabolites of biotechnological importance. These discovery efforts …

Advances in next-generation DNA sequencing technologies, bioinformatics, and mass
spectrometry-based metabolite detection have ushered in a new era of natural product …

Microorganisms are a rich source of bioactives; however, chemical identification is a major
bottleneck. Strategies that can prioritize the most prolific microbial strains and novel …

Microbial specialized metabolites are key mediators in host-microbiome interactions. Most of
the chemical space produced by the microbiome currently remains unexplored and …

Microbial and plant specialized metabolites, also known as natural products, are key
mediators of microbe-microbe and host-microbe interactions and constitute a rich resource …