Alcohol misuse is common in many societies worldwide and is associated with extensive
morbidity and mortality, often leading to alcohol use disorders (AUD) and alcohol-related …

Alcohol use disorder (AUD) is a chronic debilitating disorder with limited treatment options
and poorly defined pathophysiology. There are substantial genetic and epigenetic …

Alcohol use disorder (AUD) is closely linked to the brain regions forming the neurocircuitry of
addiction. Postmortem human brain tissue enables the direct study of the molecular …

Objective To report the genome‐wide significant and/or replicable risk variants for alcohol
dependence and explore their potential biological functions. Methods We searched in …

We report a GWAS of alcohol dependence (AD) in European-American (EA) and African-
American (AA) populations, with replication in independent samples of EAs, AAs and …

Genome-wide association studies (GWAS) of complex traits, such as alcohol use disorders
(AUD), usually identify variants in non-coding regions and cannot by themselves distinguish …

Alcohol exposure triggers changes in gene expression and biological pathways in human
brain. We explored alterations in gene expression in the Pre-Frontal Cortex (PFC) of 65 …

Previous studies using SAGE (the Study of Addiction: Genetics and Environment) and COGA
(the Collaborative Study on the Genetics of Alcoholism) genome-wide association study …

Alcohol consumption has been linked to over 200 diseases and is responsible for over 5%
of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for …

Excessive alcohol consumption is one of the main causes of death and disability worldwide.
Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of …