[HTML][HTML] The translatability of multiple sclerosis animal models for biomarkers discovery and their clinical use

D Birmpili, I Charmarke Askar, K Bigaut… - International journal of …, 2022 - mdpi.com
Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous
system which is characterized by demyelinating lesions and axonal damage. MS is a …

Preclinical models of multiple sclerosis: advantages and limitations towards better therapies

A Didonna - Current medicinal chemistry, 2016 - ingentaconnect.com
Multiple sclerosis (MS) is a disease of the central nervous system (CNS) with an unknown
etiology. MS complex pathophysiology—characterized by CNS inflammation, demyelination …

Bridging the gap from genetic association to functional understanding: the next generation of mouse models of multiple sclerosis

KE Attfield, CA Dendrou, L Fugger - Immunological reviews, 2012 - Wiley Online Library
Multiple sclerosis (MS) is a disabling autoimmune disease of the central nervous system,
which affects approximately 0.1% of the population with variable degrees of severity …

The value of animal models for drug development in multiple sclerosis

MA Friese, X Montalban, N Willcox, JI Bell, R Martin… - Brain, 2006 - academic.oup.com
The rodent model for multiple sclerosis, experimental allergic (autoimmune)
encephalomyelitis (EAE), has been used to dissect molecular mechanisms of the …

The experimental autoimmune encephalomyelitis model for proteomic biomarker studies: from rat to human

T Rosenling, A Attali, TM Luider, R Bischoff - Clinica chimica acta, 2011 - Elsevier
Multiple sclerosis (MScl) is defined by central nervous system (CNS) inflammation,
demyelination and axonal damage. Some of the disease mechanisms are known but the …

Molecular mechanisms linking neuroinflammation and neurodegeneration in MS

E Ellwardt, F Zipp - Experimental neurology, 2014 - Elsevier
Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disorder of the central
nervous system (CNS) and one of the leading causes of neurological deficits and disability …

[HTML][HTML] Molecular biomarkers in multiple sclerosis and its related disorders: A critical review

M Gul, A Azari Jafari, M Shah, S Mirmoeeni… - International journal of …, 2020 - mdpi.com
Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous
system (CNS) which can lead to severe disability. Several diseases can mimic the clinical …

[HTML][HTML] Molecular biomarkers in multiple sclerosis

T Ziemssen, K Akgün, W Brück - Journal of neuroinflammation, 2019 - Springer
Multiple sclerosis (MS) is an inflammatory-neurodegenerative disease of the central nervous
system presenting with significant inter-and intraindividual heterogeneity. However, the …

From classic to spontaneous and humanized models of multiple sclerosis: impact on understanding pathogenesis and drug development

A Ben-Nun, N Kaushansky, N Kawakami… - Journal of …, 2014 - Elsevier
Multiple sclerosis (MS), a demyelinating disease of the central nervous system (CNS),
presents as a complex disease with variable clinical and pathological manifestations …

[HTML][HTML] Molecular models of multiple sclerosis severity identify heterogeneity of pathogenic mechanisms

P Kosa, C Barbour, M Varosanec, A Wichman… - Nature …, 2022 - nature.com
While autopsy studies identify many abnormalities in the central nervous system (CNS) of
subjects dying with neurological diseases, without their quantification in living subjects …