Four NDM-1 mutants (L218T, L221T, L269H and L221T/Y229W) were generated in order to
investigate the role of leucines positioned in L10 loop. A detailed kinetic analysis stated that …

ABSTRACT The New Delhi metallo-β-lactamase-1 (NDM-1) enzyme is the most common
metallo-β-lactamase identified in many Gram-negative bacteria causing severe nosocomial …

Background New Delhi Metallo-β-Lactamase (NDM-1) is one of the most recent additions to
the β-lactamases family. Since its discovery in 2009, NDM-1 producing Enterobacteriaceae …

New Delhi metallo-β-lactamase-1 (NDM-1) has been known to hydrolyze nearly all β-lactam
antibiotics, leading to a multidrug-resistant state. Hence, it is important to study its structure …

Two accessory loop regions that are present in numerous variants of New Delhi metallo-β-
lactamases (NDM) are important for the enzymatic activity. The first one is a flexible loop L3 …

Carbapenems are one of the last lines of defense for Gram-negative pathogens, such as
members of the Enterobacteriaceae. Despite the fact that most carbapenems are resistant to …

New Delhi metallo β-lactamase-1 is one of the carbapenemases, causing hydrolysis of
almost all β-lactamase antibiotics. Seventeen different NDM variants have been reported so …

Abstract New Delhi Metallo beta-lactamase (NDM) is of significant public health concern due
to its enormous potential to hydrolyse all major beta-lactams including carbapenems. Amino …

New Delhi metallo-β-lactamase-1 (NDM-1) is expressed by various members of
Enterobacteriaceae as a defense mechanism to hydrolyze β-lactam antibiotics. Despite …

New Delhi metallo-β-lactamase (NDM) is of significant public-health concern due to its
enormous potential to hydrolyse all of the major β-lactams, including carbapenems …