Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases

VT Samuel, GI Shulman - Cell metabolism, 2018 - cell.com
NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Nonalcoholic fatty liver disease (NAFLD). Mitochondria as players and targets of therapies?

A Di Ciaula, S Passarella, H Shanmugam… - International Journal of …, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and
represents the hepatic expression of several metabolic abnormalities of high epidemiologic …

Emerging pharmacological targets for the treatment of nonalcoholic fatty liver disease, insulin resistance, and type 2 diabetes

L Goedeke, RJ Perry, GI Shulman - Annual review of …, 2019 - annualreviews.org
Type 2 diabetes (T2D) is characterized by persistent hyperglycemia despite
hyperinsulinemia, affects more than 400 million people worldwide, and is a major cause of …

Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options

C Grander, F Grabherr, H Tilg - Cardiovascular Research, 2023 - academic.oup.com
The prevalence of non-alcoholic fatty liver disease (NAFLD) is continually increasing due to
the global obesity epidemic. NAFLD comprises a systemic metabolic disease accompanied …

[HTML][HTML] Metabolic causes and consequences of nonalcoholic fatty liver disease (NAFLD)

P Zarghamravanbakhsh, M Frenkel, L Poretsky - Metabolism open, 2021 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a multifactorial metabolic disorder that was first
described in 1980. It has been prevalent and on the rise for many years and is associated …

Nonalcoholic fatty liver disease as a complication of insulin resistance

MF Abdelmalek, AM Diehl - Medical Clinics of North America, 2007 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) refers to a spectrum of liver damage ranging from
simple steatosis to nonalcoholic steatohepatitis, advanced fibrosis, and rarely, progression …

[PDF][PDF] Nonalcoholic fatty liver disease: from steatosis to cirrhosis

GC Farrell, CZ Larter - Hepatology, 2006 - Wiley Online Library
Nonalcoholic steatohepatitis (NASH), the lynchpin between steatosis and cirrhosis in the
spectrum of nonalcoholic fatty liver disorders (NAFLD), was barely recognized in 1981 …

Recent advances in nonalcoholic fatty liver disease

O Cheung, AJ Sanyal - Current opinion in gastroenterology, 2010 - journals.lww.com
The underlying mechanism and pathogenesis of NAFLD remain elusive despite ongoing
researches to make significant advances in the understanding of its natural history …

[HTML][HTML] Non-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations

S Milić, D Lulić, D Štimac - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world.
Presentation of the disease ranges from simple steatosis to non-alcoholic steatohepatitis …

Insulin resistance in nonalcoholic fatty liver disease

E Bugianesi, S Moscatiello… - Current …, 2010 - ingentaconnect.com
Nonalcoholic fatty liver disease (NAFLD) refers to a spectrum of liver damage ranging from
simple steatosis to nonalcoholic steatohepatitis (NASH), advanced fibrosis and cirrhosis …