The factors that determine persistence or clearance of hepatitis C virus (HCV) infection are
poorly understood. The CD4 T cell responses to the HCV core protein were examined in a …

Since an efficient control of virus infections may depend on the appropriate lymphokine
profile, we studied cytokine responses and CD30 induction, a recently proposed surrogate …

To investigate the involvement of T-cell response against hepatitis C virus (HCV) antigens in
viral clearance after interferon therapy, we measured interleukin-2 (IL-2) production by …

The quality of the hepatitis C virus (HCV)‐specific T‐cell response may greatly determine the
course of an HCV infection. An adequate T‐cell response may contribute to a successful …

In acute and chronic viral disease the specific response of CD4+ T lymphocytes to certain
viral proteins is an essential part of antiviral effector mechanisms. In hepatitis C virus …

A disturbing feature of hepatitis C virus (HCV) is its long-term persistence in roughly 85% of
those infected. Escape mutants may play a major role in HCV persistence. Our previous …

Patients infected with hepatitis C virus (HCV) have an impaired response against HCV
antigens while keeping immune competence for other antigens. We hypothesized that …

Since the discovery of hepatitis C virus it has become clear that chronic hepatitis C is a
major health problem throughout the world. Because antiviral agents are of limited value in …

Hepatitis C virus (HCV) is yet another example of a pathogen that persists in the presence of
a readily apparent immune response. As evidence for both humoral and cellular immune …

CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for
acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the …