The conformational restriction switch concept has been adopted as a major tool for structural
optimization of pharmaceuticals in order to expand the chemical structure scope and …

Succinate dehydrogenase (SDH) inhibitor is one of the research hotspots for the
development of fungicides. Herein, we describe the design and synthesis of N-methoxy …

Scaffold hopping strategy has become one of the most successful methods in the process of
molecular design. Seeking to develop novel succinate dehydrogenase inhibitors (SDHIs) …

A series of new fungicides that can inhibit the succinate dehydrogenase (SDH) was
classified and named as SDH inhibitors by the Fungicide Resistance Action Committee in …

To develop novel succinate dehydrogenase inhibitors (SDHIs), two series of novel N-4-
fluoro-pyrazol-5-yl-benzamide and N-4-chloro-pyrazol-5-yl-benzamide derivatives were …

To promote the discovery and development of new fungicides, a series of novel pyrazol-5-yl-
benzamide derivatives were designed, synthesized by hopping and inversion of amide …

Succinate dehydrogenase (SDH) has been demonstrated as a promising target for fungicide
discovery. Crystal structure data have indicated that the carboxyl “core” of current SDH …

Succinate dehydrogenase (SDH) is known as an ideal target for the investigations of
fungicides. To develop novel SDH inhibitors, 30 novel thiophene/furan-1, 3, 4-oxadiazole …

The discovery of novel succinate dehydrogenase inhibitors (SDHIs) has attracted great
attention worldwide. Herein, a fragment recombination strategy was proposed to design new …

Thirty-eight nicotinamide derivatives were designed and synthesized as potential succinate
dehydrogenase inhibitors (SDHI) and precisely characterized by 1H NMR, ESI-MS, and …