Toward miniaturized analysis of chemical identity and purity of radiopharmaceuticals via microchip electrophoresis

J Ly, NS Ha, S Cheung, RM van Dam - Analytical and bioanalytical …, 2018 - Springer
Miniaturized synthesis of positron emission tomography (PET) tracers is poised to offer
numerous advantages including reduced tracer production costs and increased availability …

Integration of high-resolution radiation detector for hybrid microchip electrophoresis

J Jones, NS Ha, AG Barajas… - Analytical …, 2020 - ACS Publications
For decades, there has been immense progress in miniaturizing analytical methods based
on electrophoresis to improve sensitivity and to reduce sample volumes, separation times …

Novel volumetric method for highly repeatable injection in microchip electrophoresis

NS Ha, J Ly, J Jones, S Cheung, RM van Dam - Analytica chimica acta, 2017 - Elsevier
A novel injector for microchip electrophoresis (MCE) has been designed and evaluated that
achieves very high repeatability of injection volume suitable for quantitative analysis. It …

Microfluidics: a groundbreaking technology for PET tracer production?

C Rensch, A Jackson, S Lindner, R Salvamoser… - Molecules, 2013 - mdpi.com
Application of microfluidics to Positron Emission Tomography (PET) tracer synthesis has
attracted increasing interest within the last decade. The technical advantages of …

Recent progress toward microfluidic quality control testing of radiopharmaceuticals

NS Ha, S Sadeghi, RM Van Dam - Micromachines, 2017 - mdpi.com
Radiopharmaceuticals labeled with short-lived positron-emitting or gamma-emitting isotopes
are injected into patients just prior to performing positron emission tomography (PET) or …

Microfluidic synthesis of radiotracers: recent developments and commercialization prospects

M Mc Veigh, LM Bellan - Lab on a Chip, 2024 - pubs.rsc.org
Positron emission tomography (PET) is a powerful diagnostic tool that holds incredible
potential for clinicians to track a wide variety of biological processes using specialized …

Recent applications of microchip electrophoresis to biomedical analysis

N Nuchtavorn, W Suntornsuk, SM Lunte… - … of Pharmaceutical and …, 2015 - Elsevier
Many separation methods have been developed for biomedical analysis, including
chromatographic (eg high performance liquid chromatography (HPLC) and gas …

Microchip electrophoresis with hydrodynamic injection and waste-removing function for quantitative analysis

CC Lin, CC Chen, CE Lin, SH Chen - Journal of Chromatography A, 2004 - Elsevier
Quantitative analysis is problematic for microchip electrophoresis for several reasons
including chip-to-chip variation, discontinuous sample re-loading, channel reconditioning …

Automatic concentration and reformulation of PET tracers via microfluidic membrane distillation

PH Chao, J Collins, JP Argus, WY Tseng, JT Lee… - Lab on a Chip, 2017 - pubs.rsc.org
Short-lived radiolabeled tracers for positron emission tomography (PET) must be rapidly
synthesized, purified, and formulated into injectable solution just prior to imaging. Current …

Compact microfluidic device for rapid concentration of PET tracers

WY Tseng, RM van Dam - Lab on a Chip, 2014 - pubs.rsc.org
HPLC purification and reformulation of positron emission tomography (PET) tracers can lead
to significant dilution of the final product, making it difficult to produce a sufficiently high …