Background The initiation and regulation of pulmonary fibrosis are not well understood. IL-
33, an important cytokine for respiratory diseases, is overexpressed in the lungs of patients …

The mechanisms of interstitial lung disease (ILD) remain incompletely understood, although
recent observations have suggested an important contribution by IL-33. Substantial …

Expression of IL-33 is elevated in patients with pulmonary diseases, and full-length (not
proteolytically processed) IL-33 is the predominant form in the lungs in health and disease …

IL-33 is a member of the IL-1 family and mediates its biological effects via the ST2 receptor,
which is selectively expressed on Th2 cells and mast cells. Although polymorphic variation …

Abstract IL-33 is an IL-1-related cytokine which has been implicated in Th2-associated
biology and allergic diseases in humans and mice. IL-33 stimulates Th2 cells, mast cells …

IL-33 plays an important role in inflammatory diseases including hypersensitive diseases
like asthma, autoimmune diseases like rheumatoid arthritis, cardiovascular diseases like …

Objective: To investigate the function of interleukin-33 (IL-33) in the asthmatic airway
remodeling and the relationship between IL-33 and asthma severity. Methods: IL-33 levels …

Background Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33,
thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role …

Systemic administration of IL-18 induces polyclonal IgE responses by causing NKT cells to
express CD40 ligand and to produce IL-4. Administration of IL-33 also induces IgE …

IL-33 has emerged as an important mediator in the immunopathogenesis of allergy and
asthma. However, the role of IL-33 in eosinophil-mediated inflammation has not been fully …