Examination of early phases of synucleinopathy when inclusions are present, but long
before neurodegeneration occurs, is critical to both understanding disease progression and …

Background: Parkinson's disease (PD) is a neurodegenerative disorder that is characterized
by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy bodies), markers …

Animal models that accurately recapitulate the accumulation of alpha-synuclein (α-syn)
inclusions, progressive neurodegeneration of the nigrostriatal system and motor deficits can …

The lack of disease-modifying treatments for Parkinson's disease (PD) is in part due to an
incomplete understanding of the disease's etiology. Alpha-synuclein (α-syn) has become a …

Animal models have significantly advanced our understanding of Parkinson's disease (PD).
Alpha-synuclein (α-syn) has taken center stage due to its genetic connection to familial PD …

Background Parkinson's disease (PD) is a neurodegenerative disorder that is characterized
by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy bodies), markers …

Parkinson's disease (PD) pathology is characterized by alpha-synuclein (α-syn) aggregates,
degeneration of dopamine neurons in the substantia nigra pars compacta (SNpc), and …

The use of wildtype recombinant alpha-synuclein preformed fibrils (aSyn PFFs) to induce
endogenous alpha-synuclein to form pathological phosphorylation and trigger …

Neuroinflammation has become a well-accepted pathologic hallmark of Parkinson's disease
(PD). However, it remains unclear whether inflammation, triggered by α-syn aggregation …

Protein aggregation is a predominant feature of many neurodegenerative diseases,
including synucleinopathies, which are characterized by cellular inclusions containing α …