Background The antiinflammatory, analgesic, and antipyretic actions of aspirin became well
known during the years after its introduction. More recently, the beneficial effects of the …

Cyclooxygenase (COX), also known as prostaglandin G/H synthase, is a membrane-bound
enzyme responsible for the oxidation of arachidonic acid to prostaglandins that was first …

The prostaglandins are lipid mediators, discovered in the 1930s by von Euler in Sweden
and Goldblatt in the United Kingdom. They are made by the bifunctional enzyme …

Publisher Summary Cyclooxygenase, prostaglandin synthase, is expressed in mammalian
cells as two distinct isosymes that show about 60% amino acid sequence identity. The two …

In mammalian cells, eicosanoid biosynthesis is usually initiated by the activation of
phospholipase A2 and the release of arachidonic acid from membrane phospholipids in …

Aspirin, arguably the world's favourite drug, has been around since the late nineteenth
century, but it wasn't until the late 1970s that its ability to inhibit prostaglandin production by …

Prostaglandins are formed from arachidonic acid by the action of cyclooxygenase and
subsequent downstream synthetases. Two closely related forms of the cyclooxygenase have …

Prostaglandins (PGs) play a major role in the inflam-mation process, and theinhibition of PG
production has been a common target of antiinflammatory drug dis-covery. 1· 2 Nonsteroidal …

The molecular identification of a second isoform of cyclooxygenase-2 (COX-2) led to a major
investment by several pharmaceutical companies in the development of selective inhibitors …

Accumulating evidence suggests that some enzymes exist as distinct constitutive and
inducible isoforms. The inducible isoforms are often expressed in pathophysiological …