Rationale Individuals with opioid use disorder (OUD) exhibit impaired decision making and
elevated risk-taking behavior. In contrast to the effects of natural and semi-synthetic opioids …

Rationale Most individuals can accurately assess the risks and rewards associated with
choice alternatives and decide accordingly; however, drug users often display maladaptive …

Opioid use disorder imposes great societal harm in the United States and in countries
worldwide. Animal models that accurately capture motivational changes that occur in opioid …

Drug addiction is thought to be driven by negative reinforcement, and it is thought that a shift
from positive affect upon initial exposure to negative affect after chronic exposure to a drug is …

Rationale Animal models of compulsive drug use that continues despite negative
consequences can be used to investigate the neural mechanisms of addiction. However …

Rationale Escalation of drug intake and craving are two DSM-5 hallmark symptoms of opioid
use disorder (OUD). Objectives This study determined if escalation of intake as modeled by …

Background Although fentanyl has gained widespread prominence, there remains a lack of
knowledge on the opioid synthetic agonist, particularly related to sex effects. Therefore, we …

Opioid use disorder (OUD) is a major epidemic in the United States, and fentanyl is a major
culprit. The National Institute on Drug Abuse has highlighted an urgent need for research on …

Opioid addiction/dependence is associated with impulsive and risky behavior. Moreover,
opioids can increase impulsive choice in preclinical studies with nonhumans. The objective …

Rationale Opioid use disorder (OUD) is a major epidemic in the USA. Despite evidence
indicating that OUD may be particularly severe for women, preclinical models have yet to …