In addition to the contribution of cancer cells, the solid tumor microenvironment (TME) has a
critical role in determining tumor expansion, antitumor immunity, and the response to …

Cancer immunotherapy, a promising and widely applied mode of oncotherapy, makes use of
immune stimulants and modulators to overcome the immune dysregulation present in …

Although toll-like receptor (TLR) agonists hold great promise as immune modulators for
reprogramming the suppressive immune landscape in pancreatic ductal adenocarcinoma …

Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs
and permit greater control over their pharmacokinetics, biodistribution, and bioavailability …

Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to
mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug …

While chemotherapy delivery by nanocarriers has modestly improved the survival prospects
of pancreatic ductal adenocarcinoma (PDAC), additional engagement of the immune …

We developed a custom-designed liposome carrier for codelivery of a potent immunogenic
cell death (ICD) stimulus plus an inhibitor of the indoleamine 2, 3-dioxygenase (IDO-1) …

Liposomal nanoparticles are a heterogeneous group of engineered drug carriers that have
tremendous therapeutic potential in the treatment of cancer. They increase tumor drug …

Immunotherapy provides the best approach to reduce the high mortality of metastatic breast
cancer (BC). We demonstrate a chemo-immunotherapy approach, which utilizes a liposomal …

Tumours are complex systems of genetically diverse malignant cells that proliferate in the
presence of a heterogeneous microenvironment consisting of host derived …