In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including
spermine, spermidine and putrescine, are involved in many cellular processes. Spermine …

Polyamines are organic polycations ubiquitously present in living cells. Polyamines are
involved in many cellular processes, and their content in mammalian cells is tightly …

Background: In the brain, polyamines are mainly synthesized in neurons, but preferentially
accumulated in astrocytes, and are proposed to be involved in neurodegenerative …

Transgenic mice overexpressing spermine oxidase (SMO) in the cerebral cortex (Dach-SMO
mice) showed increased vulnerability to excitotoxic brain injury and kainate-induced …

Excitotoxic stress has been associated with several different neurological disorders, and it is
one of the main causes of neuronal degeneration and death. To identify new potential …

Several studies have demonstrated high polyamine levels in brain diseases such as
epilepsy. Epilepsy is the fourth most common neurological disorder and affects people of all …

Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism,
selectively oxidizing spermine to produce H2O2, spermidine, and 3-aminopropanal …

Background Polyamine catabolism plays a key role in maintaining intracellular polyamine
pools, yet its physiological significance is largely unexplored. Here, we report that the …

Pathological activation of microglia, which reside quiescently in physiological CNS, is
associated with various neurodegenerative diseases. Endogenous polyamines, spermidine …

Diabetic Retinopathy (DR), is a significant public health issue and the leading cause of
blindness in working-aged adults worldwide. The vision loss associated with DR affects …