The cortico–basal ganglia–thalamo–cortical loop is one of the fundamental network motifs in
the brain. Revealing its structural and functional organization is critical to understanding …

The striatum (caudate-putamen) of the basal ganglia in the mammalian forebrain is a mosaic
of two interdigitating, neurochemically distinct compartments. One type, the …

The basal ganglia are phylogenetically conserved subcortical nuclei necessary for
coordinated motor action and reward learning. Current models postulate that the basal …

The cortex projects to the dorsal striatum topographically, to regulate behaviour,–, but
spiking activity in the two structures has previously been reported to have markedly different …

Neural activity during development critically shapes postnatal wiring of the mammalian
brain. This is best illustrated by the sensory systems, in which the patterned feed-forward …

Cortical columns generate separate streams of information that are distributed to numerous
cortical and subcortical brain regions. We asked whether local intracortical circuits reflect …

The basal ganglia are an interconnected set of subcortical regions whose established role in
cognition and motor control remains poorly understood. An important nucleus within the …

The human brain is comprised of a complex web of functional networks that link
anatomically distinct regions. However, the biological mechanisms supporting network …

Many tasks require rapid and fine-tuned adjustment of motor performance based on
incoming sensory information. This process of sensorimotor adaptation engages two parallel …

An unresolved question in neuroscience relates to the extent to which corticothalamocortical
circuits emanating from layer 5B are involved in information transfer through the cortical …