The many facets of macrophages in rheumatoid arthritis

E Siouti, E Andreakos - Biochemical pharmacology, 2019 - Elsevier
Macrophages are central to the pathophysiology of rheumatoid arthritis (RA). They constitute
the main source of pro-inflammatory cytokines and chemokines such as TNF and IL-1β, they …

Emerging role of targeting macrophages in rheumatoid arthritis: focus on polarization, metabolism and apoptosis

X Yang, Y Chang, W Wei - Cell proliferation, 2020 - Wiley Online Library
Macrophages maintain a dynamic balance in physiology. Various known or unknown
microenvironmental signals influence the polarization, activation and death of macrophages …

Macrophage heterogeneity in the context of rheumatoid arthritis

IA Udalova, A Mantovani, M Feldmann - Nature Reviews Rheumatology, 2016 - nature.com
Macrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The
increase in the number of sublining macrophages in the synovium is an early hallmark of …

[HTML][HTML] Macrophages: the good, the bad, and the gluttony

EA Ross, A Devitt, JR Johnson - Frontiers in immunology, 2021 - frontiersin.org
Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

The role of macrophages in rheumatoid arthritis

Y Ma, RM Pope - Current pharmaceutical design, 2005 - ingentaconnect.com
Rheumatoid arthritis (RA) is a common autoimmune chronic inflammatory joint disease,
characterized by macrophage and lymphocyte infiltration, proliferation of synovial …

Managing macrophages in rheumatoid arthritis by reform or removal

J Li, HC Hsu, JD Mountz - Current rheumatology reports, 2012 - Springer
Macrophages play a central role in the pathogenesis of rheumatoid arthritis (RA). There is
an imbalance of inflammatory and antiinflammatory macrophages in RA synovium. Although …

Macrophages and their products in rheumatoid arthritis

Z Szekanecz, AE Koch - Current opinion in rheumatology, 2007 - journals.lww.com
Macrophages and their products in rheumatoid arthritis : Current Opinion in Rheumatology
Macrophages and their products in rheumatoid arthritis : Current Opinion in Rheumatology Log …

[HTML][HTML] Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis

SK Drexler, PL Kong, J Wales, BM Foxwell - Arthritis research & therapy, 2008 - Springer
Rheumatoid arthritis is a multisystemic auto-inflammatory disease affecting up to 1% of the
population and leading to the destruction of the joints. Evidence exists for the involvement of …

[引用][C] The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases

JA Hamilton, PP Tak - Arthritis & Rheumatism, 2009 - Wiley Online Library
Like that of many other chronic inflammatory and autoimmune diseases, the etiology of
rheumatoid arthritis (RA) remains unknown, and many cell types (eg, fibroblasts …

[HTML][HTML] Macrophages in osteoarthritis: pathophysiology and therapeutics

Y Chen, W Jiang, H Yong, M He, Y Yang… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is the most common cause of disability in worldwide population, which is
characterized by cartilage breakdown, synovial fibrosis, osteophyte formation and pain …