The Mitogen-Activated Protein Kinase (MAPK) network consists of tightly interconnected
signalling pathways involved in diverse cellular processes, such as cell cycle, survival …

Background Malignant melanoma is an aggressive tumor of the skin and seems to be
resistant to current therapeutic approaches. Melanocytic transformation is thought to occur …

Cell signaling pathways control cells' responses to their environment through an intricate
network of proteins and small molecules partitioned by intracellular structures, such as the …

For more than a decade, the MAPK (mitogen-activated protein kinase) cascade has been
studied using mathematical modelling and quantitative experimentation. The MAPK cascade …

Most cancer cells harbor multiple drivers whose epistasis and interactions with expression
context clouds drug and drug combination sensitivity prediction. We constructed a …

Motivation: The modularity of biochemical networks in general, and signaling networks in
particular, has been extensively studied over the past few years. It has been proposed to be …

Mitogen-activated protein kinase (MAPK) cascades control cell fate decisions, such as
proliferation, differentiation, and apoptosis by integrating and processing intra-and …

The mitogen activated protein kinase/extracellular signal regulated kinase pathway
regulates fundamental cellular function such as cell proliferation, survival, differentiation and …

A Boolean dynamical system integrating the main signaling pathways involved in cancer is
constructed based on the currently known protein-protein interaction network. This system …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …