Stable cell pools are receiving a renewed interest as a potential alternative system to clonal
cell lines. The shorter development timelines and the capacity to achieve high product yields …

BACKGROUND The emergence of infectious diseases is accelerating the intensification of
bioprocess strategies to support the increasing demand for the manufacture of higher …

Adaptive laboratory evolution (ALE) has been extensively used to modulate the phenotype
of industrial model organisms (eg Escherichia. coli and Saccharomyces cerevisae) towards …

A baculovirus‐insect cell expression system potentially provides the means to produce
prophylactic HIV‐1 virus‐like particle (VLP) vaccines inexpensively and in large quantities …

Insect cells have shown a high versatility to produce multiple recombinant products. The
ease of culture, low contamination risk with human pathogens and high expression capacity …

The importance of developing new vaccine technologies towards versatile platforms that can
cope with global virus outbreaks has been evidenced with the most recent severe acute …

Stable insect cell lines are emerging as an alternative to the insect cell‐baculovirus
expression vector system (IC‐BEVS) for protein expression, benefiting from being a virus …

Virus-like particles (VLPs) offer great promise as candidates for new vaccine strategies.
Large-scale approaches for the manufacturing of HIV-1 Gag VLPs have mainly focused on …

Human-derived CAP-T cell line has been demonstrated to be a powerful platform for high-
titer production of HIV virus-like particles (VLPs) by PEI-mediated transient transfection …

The large‐scale production of clinical‐grade lentiviral vectors (LVs) for gene therapy
applications is a remaining challenge. The use of adherent cell lines and methods like …