Emerging evidence indicates that NOD-like receptor protein 3 (NLRP3) inflammasome-
induced inflammation plays a critical role in the pathogenesis of rheumatoid arthritis (RA) …

Clematichinenoside AR (C-AR) is a triterpene saponin isolated from the root of Clematis
manshurica Rupr., which is a herbal medicine used in traditional Chinese medicine for the …

Osteoarthritis (OA), which is characterized by proliferation of subchondral bone and the
degeneration of articular cartilage, is the most prevalent human arthritis. Nod‐like receptor …

Background Celastrol, a pentacyclic triterpenoid quinonemethide isolated from several spp.
of Celastraceae family, exhibits anti-inflammatory activities in a variety of diseases including …

The present work aimed to investigate the anti-rheumatism effect and the mechanism of
celastrol in collagen-induced arthritis (CIA) rats. The CIA model was established in male …

Invasion of fibroblast-like synoviocytes (FLSs) is critical in the pathogenesis of rheumatoid
arthritis (RA). The metalloproteinases (MMPs) and activator of Toll-like receptor 4 …

Objective Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder of the
synovial joints. Celastrol (Cel) is a quinone-methylated triterpenoid extracted from …

Knee osteoarthritis (KOA) is a disabling chronic inflammatory disease that is closely
associated with synovium tissue hypoxia and synovial fibrosis. Casticin, a compound …

The NLRP3 (NOD-like receptor protein 3) inflammasome is a caspase-1-containing
multiprotein complex that controls the release of IL-1β and has been associated with the …

Quercetin (QU) has been shown obvious anti-arthritic property in pre-clinical studies or
clinical studies. Howbeit, the underlying mechanism of it is still not revealed distinctly and …