[HTML][HTML] Formation and diversification of a paradigm biosynthetic gene cluster in plants

Z Liu, J Cheema, M Vigouroux, L Hill, J Reed… - Nature …, 2020 - nature.com
Numerous examples of biosynthetic gene clusters (BGCs), including for compounds of
agricultural and medicinal importance, have now been discovered in plant genomes …

[HTML][HTML] New and emerging concepts in the evolution and function of plant biosynthetic gene clusters

G Polturak, Z Liu, A Osbourn - Current Opinion in Green and Sustainable …, 2022 - Elsevier
Plants are a rich source of diverse chemicals. Metabolic diversification is likely a reflection of
adaptation to particular environmental niches because many of these compounds are …

[HTML][HTML] Plant biosynthetic gene clusters in the context of metabolic evolution

SJ Smit, BR Lichman - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 Plants produce a wide range of structurally and biosynthetically
diverse natural products to interact with their environment. These specialised metabolites …

[HTML][HTML] Plant metabolic gene clusters: evolution, organization, and their applications in synthetic biology

R Bharadwaj, SR Kumar, A Sharma… - Frontiers in Plant …, 2021 - frontiersin.org
Plants are a remarkable source of high-value specialized metabolites having significant
physiological and ecological functions. Genes responsible for synthesizing specialized …

Plant metabolic gene clusters in the multi-omics era

C Zhan, S Shen, C Yang, Z Liu, AR Fernie… - Trends in Plant …, 2022 - cell.com
Secondary metabolism in plants gives rise to a vast array of small-molecule natural
products. The discovery of operon-like gene clusters in plants has provided a new …

Metabolic diversification—independent assembly of operon-like gene clusters in different plants

B Field, AE Osbourn - Science, 2008 - science.org
Operons are clusters of unrelated genes with related functions that are a feature of
prokaryotic genomes. Here, we report on an operon-like gene cluster in the plant …

Formation of plant metabolic gene clusters within dynamic chromosomal regions

B Field, AS Fiston-Lavier, A Kemen… - Proceedings of the …, 2011 - National Acad Sciences
In bacteria, genes with related functions often are grouped together in operons and are
cotranscribed as a single polycistronic mRNA. In eukaryotes, functionally related genes …

[HTML][HTML] Gene clustering in plant specialized metabolism

HW Nützmann, A Osbourn - Current opinion in biotechnology, 2014 - Elsevier
Highlights•Physical clustering of genes for specialized metabolic pathways is common in
plants.•The common and individual features of plant metabolic gene clusters are …

Something old, something new: conserved enzymes and the evolution of novelty in plant specialized metabolism

GD Moghe, RL Last - Plant Physiology, 2015 - academic.oup.com
Plants produce hundreds of thousands of small molecules known as specialized
metabolites, many of which are of economic and ecological importance. This remarkable …

Making new molecules–evolution of pathways for novel metabolites in plants

DJ Kliebenstein, A Osbourn - Current opinion in plant biology, 2012 - Elsevier
Plants have adapted to their environments by diversifying in various ways. This
diversification is reflected at the phytochemical level in their production of numerous …