[HTML][HTML] High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis

ML Wikberg, S Edin, IV Lundberg, B Van Guelpen… - Tumor Biology, 2013 - Springer
An active stroma is important for cancer cell invasion and metastasis. We investigated the
expression of fibroblast activation protein (FAP) in relation to patient prognosis in colorectal …

Clinical implications of fibroblast activation protein in patients with colon cancer

LR Henry, HO Lee, JS Lee, A Klein-Szanto, P Watts… - Clinical cancer …, 2007 - AACR
Purpose: Human fibroblast activation protein (FAP)/seprase is a 97-kDa surface glycoprotein
expressed on tumor associated fibroblasts in the majority of epithelial cancers including …

[HTML][HTML] The Prognostic and therapeutic value and clinical implications of fibroblast activation protein-α as a novel biomarker in colorectal cancer

Z Kalaei, R Manafi-Farid, B Rashidi, FK Kiani… - Cell Communication and …, 2023 - Springer
The identification of contributing factors leading to the development of Colorectal Cancer
(CRC), as the third fatal malignancy, is crucial. Today, the tumor microenvironment has been …

[HTML][HTML] Fibroblast activation protein overexpression and clinical implications in solid tumors: a meta-analysis

F Liu, L Qi, B Liu, J Liu, H Zhang, DH Che, JY Cao… - PloS one, 2015 - journals.plos.org
Objective Fibroblast activation protein (FAP) plays a vital role in tumor invasion and
metastasis. Previous studies have reported its prognostic value in different tumors. However …

[HTML][HTML] High expression of FAP in colorectal cancer is associated with angiogenesis and immunoregulation processes

M Coto-Llerena, C Ercan, V Kancherla… - Frontiers in …, 2020 - frontiersin.org
Fibroblast activation protein α (FAP) plays an important role in tissue remodeling and helps
tumor cells invade surrounding tissue. We sought to investigate FAP as a prognostic …

[HTML][HTML] Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion

ML Henriksson, S Edin, AM Dahlin… - The American journal of …, 2011 - Elsevier
Cancer-associated fibroblasts expressing fibroblast activation protein (FAP) have been
implicated in the invasive behavior of colorectal cancer. In this study, we use FAP …

[HTML][HTML] Expression of fibroblast activation protein in human pancreatic adenocarcinoma and its clinicopathological significance

M Shi, DH Yu, Y Chen, CY Zhao, J Zhang… - World journal of …, 2012 - ncbi.nlm.nih.gov
AIM: To examine fibroblast activation protein (FAP) expression in pancreatic ductal
adenocarcinoma (PDAC) and to analyze its relationship with the clinicopathology of PDAC …

[HTML][HTML] Colorectal cancer cell intrinsic fibroblast activation protein alpha binds to Enolase1 and activates NF-κB pathway to promote metastasis

Z Yuan, H Hu, Y Zhu, W Zhang, Q Fang, T Qiao… - Cell death & …, 2021 - nature.com
Fibroblast activation protein alpha (FAP) is a marker of cancer-associated fibroblast, which is
also expressed in cancer epithelial cells. However, the role of FAP in colorectal cancer …

Effects of the fibroblast activation protein on the invasion and migration of gastric cancer

RF Wang, LH Zhang, LH Shan, WG Sun… - … and molecular pathology, 2013 - Elsevier
Abstract Objective Cancer-associated fibroblasts (CAFs) are one of the most important
components of tumor microenvironment. CAFs are believed to play an important role in …

[HTML][HTML] Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer

TP Sandberg, MPME Stuart, J Oosting… - BMC cancer, 2019 - Springer
Background The tumor microenvironment has a critical role in regulating cancer cell
behavior. Tumors with high stromal content are associated with poor patient outcome. The …