In humans, the thyroid hormones T3 and T4 are synthesized in the thyroid gland in a
process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of …

Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic
reticulum (ER), where it acquires N-linked glycosylation and conformational maturation …

Human thyroglobulin (TG) gene is a single copy gene, 270 kb long, that maps on
chromosome 8q24. 2–8q24. 3 and contains an 8.5-kb coding sequence divided into 48 …

Thyroglobulin (TG) defects due to TG gene mutations have an estimated incidence of
approximately 1 in 100,000 newborns. This dyshormonogenesis displays a wide phenotype …

I. Introduction N ORMAL growth and neurological development are dependent on a normal
metabolic state, conditioned by an adequate supply of thyroid hormones. Synthesis of T3 …

Thyroglobulin (TG), the primary synthetic product of the thyroid, is the macromolecular
precursor of thyroid hormones. TG synthesis, iodination, storage in follicles, and degradation …

Defective or impaired thyroglobulin (Tg) synthesis usually results in congenital goitrous
hypothyroidism, virtual absence of Tg in thyroid tissue, and the presence of an elevated …

Background: The established paradigm for thyroglobulin (Tg) function is that of a high
molecular weight precursor of the much smaller thyroid hormones, triiodothyronine (T3) and …

Impaired thyroglobulin (Tg) synthesis is one of the putative causes for dyshormonogenesis
of the thyroid gland. This type of hypothyroidism is characterized by intact iodide trapping …

Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for
growth, development and the control of metabolism in vertebrates,. Hormone synthesis from …