Roles of UVA radiation and DNA damage responses in melanoma pathogenesis

AQ Khan, JB Travers, MG Kemp - Environmental and molecular …, 2018 - Wiley Online Library
The growing incidence of melanoma is a serious public health issue that merits a thorough
understanding of potential causative risk factors, which includes exposure to ultraviolet …

Mechanisms and prevention of UV‐induced melanoma

A Sample, YY He - Photodermatology, photoimmunology & …, 2018 - Wiley Online Library
Melanoma is the deadliest form of skin cancer and its incidence is rising, creating a costly
and significant clinical problem. Exposure to ultraviolet (UV) radiation, namely UVA (315 …

UVA Radiation, DNA damage, and melanoma

SG Jin, F Padron, GP Pfeifer - ACS omega, 2022 - ACS Publications
Melanoma is a lethal type of skin tumor that has been linked with sunlight exposure chiefly in
fair-skinned human populations. Wavelengths from the sun that can reach the earth's …

The specificity of UVA-induced DNA damage in human melanocytes

S Mouret, A Forestier, T Douki - Photochemical & Photobiological …, 2012 - Springer
Exposure to solar UV radiation is the origin of most skin cancers, including deadly
melanomas. Melanomas are quite different from keratinocyte-derived tumours and exhibit a …

Unravelling UVA-induced mutagenesis

E Sage, PM Girard, S Francesconi - Photochemical & Photobiological …, 2012 - pubs.rsc.org
Ultraviolet A (UVA) radiation represents more than 90% of the solar UV radiation reaching
Earth's surface. Exposure to solar UV radiation is a major risk in the occurrence of non …

How sunlight causes melanoma

L Garibyan, DE Fisher - Current oncology reports, 2010 - Springer
The incidence of melanoma has continued to rise dramatically over the past few decades,
especially in young females. Due to the deadly nature of this disease, melanoma has …

[HTML][HTML] Ultraviolet radiation and melanomagenesis: from mechanism to immunotherapy

X Sun, N Zhang, C Yin, B Zhu, X Li - Frontiers in Oncology, 2020 - frontiersin.org
Melanoma is the deadliest form of skin cancer, and nearly 90% of melanomas are believed
to be caused by ultraviolet radiation (UVR), mainly from sunlight. UVR induces DNA …

Ultraviolet radiation and cutaneous malignant melanoma

C Jhappan, FP Noonan, G Merlino - Oncogene, 2003 - nature.com
Recent years have seen a steady rise in the incidence of cutaneous malignant melanoma
worldwide. Although it is now appreciated that the key to understanding the process by …

Role of UVA in the pathogenesis of melanoma and non‐melanoma skin cancer: A short review

TM Rünger - Photodermatology, Photoimmunology & …, 1999 - Wiley Online Library
It is well established, at least in mice, that not only ultraviolet C (UVC) or ultraviolet B (UVB),
but also ultraviolet A (UVA) is able to induce squamous cell carcinomas. Results from animal …

Stepping up melanocytes to the challenge of UV exposure

ZA Abdel‐Malek, AL Kadekaro… - Pigment cell & …, 2010 - Wiley Online Library
Exposure to solar ultraviolet radiation (UV) is the main etiological factor for skin cancer,
including melanoma. Cutaneous pigmentation, particularly eumelanin, afforded by …