The aim of this review is to explore how metabolic changes induced by diets high in
saturated fat (HFD) affect nucleus accumbens (NAc) dopamine neurotransmission and food …

Highlights•Chronic high-fat feeding modulates dopamine tone and function.•The impact of
high-fat diet on dopamine-related endpoints is inconsistent.•Classification of results …

Objective We have previously demonstrated that insulin signaling, through the downstream
signaling kinase Akt, is a potent modulator of dopamine transporter (DAT) activity, which fine …

Abstract Purpose of Review Animal and human studies suggest that diet-induced obesity
and plasticity in the central dopaminergic system are linked. However, it is unclear whether …

Obesity has reached epidemic prevalence, and much research has focused on homeostatic
and nonhomeostatic mechanisms underlying overconsumption of food. Mesocorticolimbic …

Food intake, which is a highly reinforcing behavior, provides nutrients required for survival in
all animals. However, when fat and sugar consumption goes beyond the daily needs, it can …

Abstract Purpose of Review Dietary obesity is primarily attributed to an imbalance between
food intake and energy expenditure. Adherence to lifestyle interventions reducing weight is …

Western diets rich in fat and sugar promote excess calorie intake and weight gain; however,
the underlying mechanisms are unclear. Despite a well-documented association between …

Overconsumption of high caloric food plays an important role in the etiology of obesity.
Several factors drive such hedonic feeding. High caloric food is often palatable. In addition …

Background The prevalence of obesity has increased dramatically worldwide. The obesity
epidemic begs for novel concepts and therapeutic targets that cohesively address “food …