WNT2 acts as a pro-angiogenic factor in placental vascularization and increases
angiogenesis in liver sinusoidal endothelial cells (ECs) and other ECs. Increased WNT2 …

Abstract Background Wingless and Int-related protein (Wnt) ligands are aberrantly
expressed in patients with colorectal cancer (CRC). However, the aberrant level of Wnt …

The canonical WNT signaling pathway is crucial for intestinal stem cell renewal and aberrant
WNT signaling is an early event in colorectal cancer (CRC) development. Here, we show for …

Simple Summary Angiogenesis belongs to the most clinical characteristics of colorectal
cancer (CRC) and is strongly linked to the activation of Wnt/β-catenin signaling. The most …

Introduction Epithelial–mesenchymal transition (EMT) contributes to the progression and
metastasis of cancer cells and is associated with a more invasive phenotype of cancer. The …

Recent studies have shown that the tumor microenvironment plays a significant role in the
progression of solid tumors. As an abundant component of the tumor microenvironment …

Our previous study provided evidence that non-canonical Wnt signaling is involved in
regulating vasculogenic mimicry (VM) formation. However, the functions of canonical Wnt …

Wnts are lipid-modified secreted glycoproteins that regulate diverse biological processes.
We report that Wnt5a, which functions in noncanonical Wnt signaling, has activity on …

Angiogenesis is a normal biological process wherein new blood vessels form from the
growth of pre-existing blood vessels. Preventing angiogenesis in solid tumours by targeting …

Objective: Direct interaction with cancer-associated fibroblasts triggers WNT5A expression
in human gastric carcinoma (GC) cells. In this study, we performed gene transduction …