Infection with hepatitis C virus (HCV), which is distributed worldwide, often becomes
persistent, causing chronic hepatitis, cirrhosis, and hepatocellular carcinoma. For many …

There has been major progress in our understanding of hepatitis C virus (HCV) molecular
virology in recent years. An essential prerequisite for this progress was the availability of …

The hepatitis C virus (HCV) is a positive-strand RNA virus that belongs to the genus
Hepacivirus of the family Flaviviridae. The development of a system to propagate this human …

Hepatitis C virus (HCV) chronically infects approximately 170 million people worldwide, with
an increased risk of developing cirrhosis and hepatocellular carcinoma. The study of HCV …

Hepatitis C virus (HCV) is a major cause of chronic liver disease, frequently progressing to
cirrhosis and increased risk of hepatocellular carcinoma. Current therapies are inadequate …

Infections with the hepatitis C virus (HCV) are a major cause of acute and chronic liver
disease. The high prevalence of the virus, the insidious course of the disease and the poor …

T7 RNA polymerase transcripts of a putative full-length cDNA clone of hepatitis C virus type
1 (HCV-1) were used to transfect a differentiated human hepatoma cell line, Huh7. The …

Since the molecular cloning of the hepatitis C virus (HCV) genome for the first time in 1989,
there has been tremendous progress in our understanding of the multiple facets of the …

The hepatitis C virus (HCV) replicon system is a potent tool for understanding the
mechanisms of HCV replication and proliferation, and for the development of treatments for …

Progress in understanding hepatitis C virus (HCV) biology has remained a challenge due to
the lack of an efficient cell culture system for virus growth. In this study, we examined HCV …