Neurotropic strains of the mouse hepatitis virus (MHV) cause a range of diseases in infected
mice ranging from mild encephalitis with clearance of the virus followed by demyelination to …

Mouse hepatitis virus (MHV) is a positive-strand RNA virus that causes an acute
encephalomyelitis that later resolves into a chronic fulminating demyelinating disease …

Neurological disease induced by neurotropic coronaviruses has received considerable
attention not only as a model for virus induced demyelination, but also of immune regulation …

The route of entry into the central nervous system (CNS) of most neurotropic viruses has not
been established. The coronavirus, mouse hepatitis virus strain JHM (MHV-JHM), causes …

Murine coronavirus, mouse hepatitis virus (MHV), causes various diseases depending on
the strain and route of inoculation. Both the JHM and A59 strains, when inoculated …

1. INTRODUCTION tracts as well as the central nervous system (CNS). Infections of the CNS
provide a unique challenge to the host. Rapid responses are vital to control the pathogen yet …

Viral infection of the central nervous system (CNS) results in varied outcomes ranging from
encephalitis, paralytic poliomyelitis or other serious consequences. One of the principal …

Mice infected with the neurotropic coronavirus mouse hepatitis virus strain JHM (MHV-JHM)
develop a chronic demyelinating disease with symptoms of hindlimb paralysis. Histological …

Inoculation of mice with most neurotropic strains of the coronavirus mouse hepatitis virus
results in an immune response-mediated demyelinating disease that serves as an excellent …

Mice infected with mouse hepatitis virus strain JHM (MHV-JHM) develop a chronic
demyelinating encephalomyelitis that is in large part immune mediated. Potential …