Inflammation, especially chronic inflammation, is closely linked to tumor development. As
essential chronic inflammatory cytokines, the interleukin family plays a key role in …

Polymorphism of IL-1 receptor antagonist gene: role in cancer. - Abstract - Europe PMC Sign in
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Inflammatory abnormalities have been implicated in the pathogenesis of various human
diseases, including cancer. Interleukin-1 receptor antagonist (IL1RN) is a potent anti …

The tumor microenvironment consists of tumor, immune, stromal, and inflammatory cells
which produce cytokines, growth factors, and adhesion molecules that promote tumor …

More than any other family, the IL-1 Family of 11 cytokines and 10 receptors provides the
host with an endogenous innate immune system, whereas the family of Toll-like Receptors …

Abstract The interleukin-1 (IL-1) family is one of the first described cytokine families and
consists of eight cytokines (IL-1β, IL-1α, IL-18, IL-33, IL-36α, IL-36β, IL-36γ and IL-37) and …

The IL-1 family of cytokines consists of IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ.
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …

Summary Interleukin-1 (IL-1) is a key orchestrator of inflammation and plays an important
role in tumor progression. Based on preclinical models and human genetic associations, we …

The interleukin-1 receptor antagonist (IL-1Ra) is an anti-inflammatory cytokine and a
naturally occurring antagonist of the IL-1 receptor. It effectively counteracts the IL-1 signaling …

Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …