Multi-omics approaches to improve malaria therapy
M Zhou, A Varol, T Efferth - Pharmacological Research, 2021 - Elsevier
Malaria contributes to the most widespread infectious diseases worldwide. Even though
current drugs are commercially available, the ever-increasing drug resistance problem by …
current drugs are commercially available, the ever-increasing drug resistance problem by …
Proteomic approaches to studying drug targets and resistance in Plasmodium
RA Cooper, DJ Carucci - Current Drug Targets-Infectious …, 2004 - ingentaconnect.com
Ever increasing drug resistance by Plasmodium falciparum, the most virulent of human
malaria parasites, is creating new challenges in malaria chemotherapy. The entire genome …
malaria parasites, is creating new challenges in malaria chemotherapy. The entire genome …
Recent updates in the discovery and development of novel antimalarial drug candidates
Though morbidity and mortality due to malaria have declined in the last 15 years, emerging
resistance to first-line artemisinin-based antimalarials, absence of efficacious vaccines and …
resistance to first-line artemisinin-based antimalarials, absence of efficacious vaccines and …
Advances in drug discovery based on genomics, proteomics and bioinformatics in malaria
S Aggarwal, A Karmakar… - Current Topics in …, 2023 - ingentaconnect.com
Malaria is one of the neglected infectious diseases, and drugs are the first line of action
taken against the onset of malaria as therapeutics. The drugs can be of either natural or …
taken against the onset of malaria as therapeutics. The drugs can be of either natural or …
[HTML][HTML] Designing the next generation of medicines for malaria control and eradication
JN Burrows, R Hooft van Huijsduijnen, JJ Möhrle… - Malaria journal, 2013 - Springer
In the fight against malaria new medicines are an essential weapon. For the parts of the
world where the current gold standard artemisinin combination therapies are active …
world where the current gold standard artemisinin combination therapies are active …
[HTML][HTML] Metabolic profiling framework for discovery of candidate diagnostic markers of malaria
L Tritten, J Keiser, M Godejohann, J Utzinger… - Scientific reports, 2013 - nature.com
Despite immense efforts to combat malaria in tropical and sub-tropical regions, the potency
of this vector-borne disease and its status as a major driver of morbidity and mortality remain …
of this vector-borne disease and its status as a major driver of morbidity and mortality remain …
Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38
JF Armstrong, B Campo, SPH Alexander… - British Journal of …, 2023 - Wiley Online Library
Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic
cellular screening, allowing millions of compounds to be assayed and delivering clinical …
cellular screening, allowing millions of compounds to be assayed and delivering clinical …
New medicines to improve control and contribute to the eradication of malaria
TNC Wells, PL Alonso, WE Gutteridge - Nature reviews Drug discovery, 2009 - nature.com
Despite being one of the most prevalent tropical diseases, for many years malaria was not a
commercial priority for the pharmaceutical industry. However, in response to the emergence …
commercial priority for the pharmaceutical industry. However, in response to the emergence …
Current status of malaria control
RP Tripathi, RC Mishra, N Dwivedi… - Current medicinal …, 2005 - ingentaconnect.com
Malaria caused by Plasmodium parasites kills approximately 1-3 million people and causes
disease in 300-500 million people annually throughout the world. The current approaches to …
disease in 300-500 million people annually throughout the world. The current approaches to …
Novel antimalarial drug targets: hope for new antimalarial drugs
Malaria is a major global threat, that results in more than 2 million deaths each year. The
treatment of malaria is becoming extremely difficult due to the emergence of drug-resistant …
treatment of malaria is becoming extremely difficult due to the emergence of drug-resistant …