After the first ancient studies on microbial slime (the name by which the biofilm matrix was
initially indicated), multitudes of studies on the morphology, composition and physiology of …

The significance of extracellular DNA (eDNA) in biofilms was overlooked until researchers
added DNAse to a Pseudomonas aeruginosa biofilm and watched the biofilm disappear …

Advances in biotechnology to treat and cure human disease have markedly improved
human health and the development of modern societies. However, substantial challenges …

Bacteria adhere to natural and engineered surfaces and develop into mature biofilms
encased in self‐produced extracellular polymeric substances (EPSs). EPS consists of …

Extracellular DNA (eDNA) is an important biofilm component that was recently discovered.
Its presence has been initially observed in biofilms of Pseudomonas aeruginosa …

Highlights•eDNA is a key component of the biofilm matrix of most bacteria.•DNase inhibits
biofilm formation and disperses young biofilms.•DNase treatment can sensitize biofilms to …

Bacteria that cause chronic and/or recurrent diseases often rely on a biofilm lifestyle. The
foundation of the biofilm structure is the extracellular polymeric substance (EPS) that acts as …

Staphylococcus aureus is an important human pathogen that can form biofilms on various
surfaces. These cell communities are protected from the environment by a self-produced …

We developed a new approach that couples Southwestern blotting and mass spectrometry
to discover proteins that bind extracellular DNA (eDNA) in bacterial biofilms. Using …

Extracellular DNA (eDNA) plays an important role in both the aggregation of bacteria and in
the interaction of the resulting biofilms with polymorphonuclear leukocytes (PMNs) during an …