The tumor microenvironment (TME) is connected to immunotherapy responses, but it
remains unclear how cancer cells and host tissues differentially influence the immune …

Antitumoral immunity requires organized, spatially nuanced interactions between
components of the immune tumor microenvironment (iTME). Understanding this coordinated …

Simple Summary Colorectal cancer (CRC) is the third most common cancer worldwide.
Metastasis to secondary organs, such as the liver and lungs, is a key driver of CRC-related …

Purpose: The liver is the most frequent metastatic site for colorectal cancer. Its
microenvironment is modified to provide a niche that is conducive for colorectal cancer cell …

Metastasis is the primary cause of cancer-related mortality in colorectal cancer (CRC)
patients. How to improve therapeutic options for patients with metastatic CRC is the core …

Over the past decade, growing evidence indicates that the tumor microenvironment (TME)
contributes with genomic/epigenomic aberrations of malignant cells to enhance cancer cells …

Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among
patients with colorectal cancer (CRC). Although immunotherapy has demonstrated …

Cancer immunotherapy has revolutionized cancer treatment, and it relies heavily on the
comprehensive understanding of the immune landscape of the tumor microenvironment …

Paramount to the efficacy of immune checkpoint inhibitors is proper selection of patients with
adequate tumor immunogenicity and a robust but suppressed immune infiltrate. In colon …

Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly
heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 …