Nox generated ROS, particularly those derived from Nox1, Nox2 and Nox4, have emerged
as important regulators of the actin cytoskeleton and cytoskeleton-supported cell functions …

Significance: The majority of cells in a multi-cellular organism are continuously exposed to
ever-changing physical forces. Mechano-transduction links these events to appropriate …

Generation of reactive oxygen species (ROS) by Ras oncogene-induced NADPH oxidase
(Nox) 1 is required for Ras transformation phenotypes including anchorage-independent …

Abstract Significance: Rho GTPases are historically known to be central regulators of actin
cytoskeleton reorganization. This affects many processes including cell migration. In …

Significance: Understanding isoform-and context-specific subcellular Nox reduced
nicotinamide adenine dinucleotide phosphate (NADPH) oxidase compartmentalization …

The NADPH oxidase (Nox) family of superoxide (O2−) and hydrogen peroxide (H2O2)-
producing proteins has emerged as an important source of reactive oxygen species (ROS) …

Significance: NOX2 is important for host defense, and yet is implicated in a large number of
diseases in which inflammation plays a role in pathogenesis. These include acute and …

Significance: Adhesion and migration induced by cytokines or growth factors are well-
organized processes in cellular motility. Reactive oxygen species (ROS) are specifically …

Reactive oxygen species (ROS) control the integrity of the vascular endothelium. Our
laboratory has recently shown that transduction of human umbilical vein endothelial cells …

The Nox field (for review see [3, 4] has seen two distinct epochs:(1) the Age of the Phagocyte
Oxidase, which began in earnest more than 30 years ago, during which the respiratory burst …