Neurofilament proteins (Nf) have been validated and established as a reliable body fluid
biomarker for neurodegenerative pathology. This review covers seven Nf isoforms, Nf light …

Neurofilaments: light, medium, and heavy (abbreviated as NF-L, NF-M, and NF-H,
respectively), which belong to Type IV intermediate filament family (IF), are neuron-specific …

Biomarkers of neurodegeneration and neuronal injury have the potential to improve
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …

Abstract Background Neurofilaments (Nfs) are protein biomarkers of neurodegeneration in
human disease. There is in vivo evidence of changes of the Nf stoichiometry in the …

Neurofilaments (NF) are the most abundant cytoskeletal component of large myelinated
axons from adult central and peripheral nervous system. Here, we provide an overview of …

Neurofilaments (NF), a class ofintermediate filaments specialized for the neuronal
cytoskeleton, have evolved in vertebrates as heteropolymers composed of three subunit …

In the last two years, neurofilaments (NFs) have become one of the most blazing topics in
clinical neuroscience. NFs are major cytoskeletal constituents of neurons, can be detected in …

Neurofilament proteins have been validated as specific body fluid biomarkers of neuro-
axonal injury. The advent of highly sensitive analytical platforms that enable reliable …

Neurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …

Highlights•Neurofilament levels are elevated in most neurodegenerative conditions.•Levels
predict cross-sectional and longitudinal cognitive and clinical outcomes.•There is minimal …