Tetra-substituted pyrazole analogues: synthesis, molecular docking, ADMET prediction, antioxidant and pancreatic lipase inhibitory activities
The development of novel analogues for the pancreatic lipase (PL) inhibitors and
antioxidant candidates remains a significant research objective, as these studies are …
antioxidant candidates remains a significant research objective, as these studies are …
Amino acid and dicyclohexylurea linked pyrazole analogues: Synthesis, in silico and in vitro studies
Pancreatic lipase (PL) inhibitors have received considerable attention by several
researchers because of its ability to hydrolyse the triglycerides in the small intestine. This …
researchers because of its ability to hydrolyse the triglycerides in the small intestine. This …
Design, Synthesis, and Structure‐Activity Relationship Study of Pyrazolones as Potent Inhibitors of Pancreatic Lipase
J Zhang, Y Yang, XK Qian, PF Song, YS Zhao… - …, 2021 - Wiley Online Library
Pancreatic lipase (PL), a key target for the prevention and treatment of obesity, plays crucial
roles in the hydrolysis and absorption of in dietary fat. In this study, a series of pyrazolones …
roles in the hydrolysis and absorption of in dietary fat. In this study, a series of pyrazolones …
In Silico and in Vitro Biological Evaluation of Novel Serial Sulfonate Derivatives on Pancreatic Lipase Activity
The novel benzothiazole sulfonate hybrid derivatives containing azomethine group were
synthesized and characterized using 1H‐NMR, 13C‐NMR, and HR‐MS analysis. The …
synthesized and characterized using 1H‐NMR, 13C‐NMR, and HR‐MS analysis. The …
Design, synthesis, spectroscopic characterizations, in vitro pancreatic lipase as well as tyrosinase inhibition evaluations and in silico analysis of novel aryl sulfonate …
One of the primary purposes of this study is to synthesize new aryl sulfonate-naphthalene
hybrid structures possessing divergent electron-withdrawing and electron-releasing …
hybrid structures possessing divergent electron-withdrawing and electron-releasing …
Design, synthesis, biological evaluation and molecular modelling studies of novel diaryl substituted pyrazolyl thiazolidinediones as potent pancreatic lipase inhibitors
SNC Sridhar, D Bhurta, D Kantiwal, G George… - Bioorganic & medicinal …, 2017 - Elsevier
A series of novel diaryl substituted pyrazolyl 2, 4-thiazolidinediones were synthesized via
reaction of appropriate pyrazolecarboxaldehydes with 2, 4-thiazolidinedione (TZD) and …
reaction of appropriate pyrazolecarboxaldehydes with 2, 4-thiazolidinedione (TZD) and …
Synthesis, molecular modelling and pharmacological evaluation of novel indole-thiazolidinedione based hybrid analogues as potential pancreatic lipase inhibitors
A series of novel indole-thiazolidinedione hybrid analogues (7a to 7 u) were synthesised,
characterised and evaluated for their potential Pancreatic Lipase (PL) inhibition. Amongst …
characterised and evaluated for their potential Pancreatic Lipase (PL) inhibition. Amongst …
Glutathione Peroxidase-like Antioxidant Activity of 1,3-Benzoselenazoles: Synthesis and In Silico Molecular Docking Studies as Pancreatic Lipase Inhibitors
M Yadav, VP Singh - The Journal of Organic Chemistry, 2023 - ACS Publications
The synthesis of 1, 3-benzoselenazoles was achieved by the reaction of corresponding bis
[3-amino-N-(p-tolyl) benzamide-2-yl] diselenide, bis [3-amino-N-(4-methoxyphenyl) …
[3-amino-N-(p-tolyl) benzamide-2-yl] diselenide, bis [3-amino-N-(4-methoxyphenyl) …
Dihydropyrazole derivatives act as potent α-amylase inhibitors and free radical scavengers: synthesis, bioactivity evaluation, structure–activity relationship, ADMET …
A Ali, MIA Shah, C Fu, Z Hussain, MN Qureshi… - ACS …, 2023 - ACS Publications
Dihydropyrazole (1–22) derivatives were synthesized from already synthesized chalcones.
The structures of all of the synthesized compounds were confirmed by elemental analysis …
The structures of all of the synthesized compounds were confirmed by elemental analysis …
Synthesis, structural characterizations, in vitro biological evaluation and computational investigations of pyrazole derivatives as potential antidiabetic and antioxidant …
S Mortada, K Karrouchi, EH Hamza, A Oulmidi… - Scientific Reports, 2024 - nature.com
In this study, a two pyrazole derivatives; 2-(5-methyl-1H-pyrazole-3-carbonyl)-N-
phenylhydrazine-1-carboxamide (Pyz-1) and 4-amino-5-(5-methyl-1H-pyrazol-3-yl)-4H-1, 2 …
phenylhydrazine-1-carboxamide (Pyz-1) and 4-amino-5-(5-methyl-1H-pyrazol-3-yl)-4H-1, 2 …
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