Tetra-substituted pyrazole analogues: synthesis, molecular docking, ADMET prediction, antioxidant and pancreatic lipase inhibitory activities

A Cetin, A Donmez, A Dalar, I Bildirici - Medicinal Chemistry Research, 2023 - Springer
The development of novel analogues for the pancreatic lipase (PL) inhibitors and
antioxidant candidates remains a significant research objective, as these studies are …

Amino acid and dicyclohexylurea linked pyrazole analogues: Synthesis, in silico and in vitro studies

A Cetin, A Donmez, A Dalar, I Bildirici - ChemistrySelect, 2023 - Wiley Online Library
Pancreatic lipase (PL) inhibitors have received considerable attention by several
researchers because of its ability to hydrolyse the triglycerides in the small intestine. This …

Design, Synthesis, and Structure‐Activity Relationship Study of Pyrazolones as Potent Inhibitors of Pancreatic Lipase

J Zhang, Y Yang, XK Qian, PF Song, YS Zhao… - …, 2021 - Wiley Online Library
Pancreatic lipase (PL), a key target for the prevention and treatment of obesity, plays crucial
roles in the hydrolysis and absorption of in dietary fat. In this study, a series of pyrazolones …

In Silico and in Vitro Biological Evaluation of Novel Serial Sulfonate Derivatives on Pancreatic Lipase Activity

F Yetişsin, A Korkmaz, E Kaya - Chemistry & Biodiversity, 2023 - Wiley Online Library
The novel benzothiazole sulfonate hybrid derivatives containing azomethine group were
synthesized and characterized using 1H‐NMR, 13C‐NMR, and HR‐MS analysis. The …

Design, synthesis, spectroscopic characterizations, in vitro pancreatic lipase as well as tyrosinase inhibition evaluations and in silico analysis of novel aryl sulfonate …

A Korkmaz, G Kurtay, E Kaya… - Journal of Biomolecular …, 2023 - Taylor & Francis
One of the primary purposes of this study is to synthesize new aryl sulfonate-naphthalene
hybrid structures possessing divergent electron-withdrawing and electron-releasing …

Design, synthesis, biological evaluation and molecular modelling studies of novel diaryl substituted pyrazolyl thiazolidinediones as potent pancreatic lipase inhibitors

SNC Sridhar, D Bhurta, D Kantiwal, G George… - Bioorganic & medicinal …, 2017 - Elsevier
A series of novel diaryl substituted pyrazolyl 2, 4-thiazolidinediones were synthesized via
reaction of appropriate pyrazolecarboxaldehydes with 2, 4-thiazolidinedione (TZD) and …

Synthesis, molecular modelling and pharmacological evaluation of novel indole-thiazolidinedione based hybrid analogues as potential pancreatic lipase inhibitors

G George, PS Auti, P Sengupta, N Yadav… - Journal of Biomolecular …, 2023 - Taylor & Francis
A series of novel indole-thiazolidinedione hybrid analogues (7a to 7 u) were synthesised,
characterised and evaluated for their potential Pancreatic Lipase (PL) inhibition. Amongst …

Glutathione Peroxidase-like Antioxidant Activity of 1,3-Benzoselenazoles: Synthesis and In Silico Molecular Docking Studies as Pancreatic Lipase Inhibitors

M Yadav, VP Singh - The Journal of Organic Chemistry, 2023 - ACS Publications
The synthesis of 1, 3-benzoselenazoles was achieved by the reaction of corresponding bis
[3-amino-N-(p-tolyl) benzamide-2-yl] diselenide, bis [3-amino-N-(4-methoxyphenyl) …

Dihydropyrazole derivatives act as potent α-amylase inhibitors and free radical scavengers: synthesis, bioactivity evaluation, structure–activity relationship, ADMET …

A Ali, MIA Shah, C Fu, Z Hussain, MN Qureshi… - ACS …, 2023 - ACS Publications
Dihydropyrazole (1–22) derivatives were synthesized from already synthesized chalcones.
The structures of all of the synthesized compounds were confirmed by elemental analysis …

Synthesis, structural characterizations, in vitro biological evaluation and computational investigations of pyrazole derivatives as potential antidiabetic and antioxidant …

S Mortada, K Karrouchi, EH Hamza, A Oulmidi… - Scientific Reports, 2024 - nature.com
In this study, a two pyrazole derivatives; 2-(5-methyl-1H-pyrazole-3-carbonyl)-N-
phenylhydrazine-1-carboxamide (Pyz-1) and 4-amino-5-(5-methyl-1H-pyrazol-3-yl)-4H-1, 2 …