The formalin test still surprises with its biphasic pain-related behavior resulting from a
quiescent interphase that does not occur with other algogenic compounds and remains …

The formalin model is widely used for evaluating the effects of analgesic compounds in
laboratory animals. Injection of formalin into the hind paw induces a biphasic pain response; …

The orofacial formalin test in the rat is a valid and reliable model of nociception and is
sensitive to various classes of analgesic drugs. The noxious stimulus consists in an injection …

The formalin test is the most widely used behavioral screening test for analgesic
compounds. The cellular mechanism of action of formaldehyde, inducing a typically biphasic …

Pain research is mostly based on experimental assays that use animal models, which may
allow deciphering the physiopathology of this condition and to propel drug discovery. The …

The most widely used formalin test to screen antinociceptive drug candidates is still
apostrophized as targeting inflammatory pain, in spite of strong opposing evidence …

Formalin injected subcutaneously into the paw is a frequently used pain assay; it evokes an
initial period of licking and flinching followed by a period of quiescence and last by a second …

Although formalin-induced activity in primary afferent fibers and spinal dorsal horn is well
described, the forebrain neural basis underlying each phase of behavior in formalin test has …

The formalin test was introduced as a model of tonic pain in 1977, and has since been used
extensively in rats and mice. In rats, formalin generates an initial phase of activity (5–10 min …

This is the first neural imaging study to use regional cerebral blood flow (rCBF) in an animal
model to identify the patterns of forebrain nociceptive processing that occur during the early …