[HTML][HTML] SHC4 promotes tumor proliferation and metastasis by activating STAT3 signaling in hepatocellular carcinoma
X Zhang, H Zhang, Z Liao, J Zhang, H Liang… - Cancer Cell …, 2022 - Springer
Abstract Background The Src homology and collagen 4 (SHC4) is an important intracellular
adaptor protein that has been shown to play a pro-cancer role in melanoma and glioma …
adaptor protein that has been shown to play a pro-cancer role in melanoma and glioma …
Demethylation-Induced Overexpression of Shc3 Drives c-Raf–Independent Activation of MEK/ERK in HCC
Y Liu, X Zhang, B Yang, H Zhuang, H Guo, W Wei, Y Li… - Cancer Research, 2018 - AACR
Invasion and intrahepatic metastasis are major factors of poor prognosis in patients with
hepatocellular carcinoma (HCC). In this study, we show that increased Src homolog and …
hepatocellular carcinoma (HCC). In this study, we show that increased Src homolog and …
SHC1 promotes lung cancer metastasis by interacting with EGFR
P Yang, W Li, X Li - Journal of Oncology, 2022 - Wiley Online Library
The study aims to explore the biological function of SHC1 in the development and
progression of lung cancer. Meanwhile, the effect of SHC1 and EGFR on lung cancer was …
progression of lung cancer. Meanwhile, the effect of SHC1 and EGFR on lung cancer was …
[HTML][HTML] Overexpression of SH2D1A promotes cancer progression and is associated with immune cell infiltration in hepatocellular carcinoma via bioinformatics and in …
QM Xiang, N Jiang, YF Liu, YB Wang, DA Mu, R Liu… - BMC cancer, 2023 - Springer
Background SH2 domain containing 1A (SH2D1A) expression has been linked to cancer
progression. However, the functions of SH2D1A in hepatocellular carcinoma (HCC) have …
progression. However, the functions of SH2D1A in hepatocellular carcinoma (HCC) have …
[HTML][HTML] SH2B1 promotes NSCLC cell proliferation through PI3K/Akt/mTOR signaling cascade
S Wang, Y Zheng, Z He, W Zhou, Y Cheng… - Cancer Cell …, 2018 - Springer
Background Non-small cell lung cancer (NSCLC), the most prevalent type of human lung
cancer, is characterized by many molecular abnormalities. SH2B1, a member of the SH2 …
cancer, is characterized by many molecular abnormalities. SH2B1, a member of the SH2 …
[HTML][HTML] SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules
L Quagliata, M Andreozzi, M Kovac, L Tornillo… - European Journal of …, 2014 - Elsevier
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death
worldwide. The lack of effective therapeutic options for advanced stage HCCs combined …
worldwide. The lack of effective therapeutic options for advanced stage HCCs combined …
[HTML][HTML] SH2D4A inhibits esophageal squamous cell carcinoma progression through FAK/PI3K/AKT signaling pathway
H Shi, J Luo, L Ye, C Duan, M Zhang, H Ran, C Li… - Cellular …, 2024 - Elsevier
Esophageal squamous cell carcinoma (ESCC), one of the most common malignant tumors,
is now afflicting approximately 80% of patients diagnosed with esophageal cancers. The …
is now afflicting approximately 80% of patients diagnosed with esophageal cancers. The …
SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis
F Chen, L Aye, L Yu, L Liu, Y Liu, Y Lin, D Gao… - …, 2023 - academic.oup.com
Protein tyrosine phosphatases (PTPs) are involved in malignant transformation and
metastasis. According to one of our previous studies, Slingshot homolog 1 (SSH1), a …
metastasis. According to one of our previous studies, Slingshot homolog 1 (SSH1), a …
[HTML][HTML] Shc3 promotes hepatocellular carcinoma stemness and drug resistance by interacting with β-catenin to inhibit its ubiquitin degradation pathway
Y Liu, H Zhuang, F Cao, J Li, Y Guo, J Zhang… - Cell Death & …, 2021 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common cancers with an insidious
onset, strong invasiveness, insensitivity to chemotherapy, and poor prognosis, thus makes …
onset, strong invasiveness, insensitivity to chemotherapy, and poor prognosis, thus makes …
Involvement of PI3K/Akt pathway in the inhibition of hepatocarcinoma cell invasion and metastasis induced by SASH1 through downregulating Shh-Gli1 signaling
C Sun, Z Zhang, P He, Y Zhou, X Xie - The International Journal of …, 2017 - Elsevier
The SASH1 gene is discovered as a tumor suppressor recently. However, the molecular
mechanisms of SASH1 in hepatocarcinoma (HCC) remain unclear. In present studies, we …
mechanisms of SASH1 in hepatocarcinoma (HCC) remain unclear. In present studies, we …